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Multifunctional Magnetic Nanoparticles-Labeled Mesenchymal Stem Cells for Hyperthermia and Bioimaging Applications Publisher Pubmed



Ghorbanzade S1 ; Naghib SM1 ; Sadr A2 ; Fateminia FS1, 3 ; Ghaffarinejad A4, 5 ; Majidzadeha K3 ; Sanatinezhad A6, 7
Authors
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Authors Affiliations
  1. 1. Nanotechnology Department, School of Advanced Technologies, Iran University of Science and Technology (IUST), Tehran, Iran
  2. 2. Department of Electrical Engineering, Iran University of Science and Technology, Tehran, Iran
  3. 3. Interdisciplinary Technologies Department, Breast Cancer Research Center, Motamed Cancer Institute, ACECR, Tehran, Iran
  4. 4. Research Laboratory of Real Samples Analysis, Faculty of Chemistry, Iran University of Science and Technology (IUST), Tehran, Iran
  5. 5. Electroanalytical Chemistry Research Center, Iran University of Science and Technology (IUST), Tehran, Iran
  6. 6. BioMEMS and Bioinspired Microfluidic Laboratory, Department of Mechanical and Manufacturing Engineering, University of Calgary, Calgary, AB, Canada
  7. 7. Center for BioEngineering Research and Education, University of Calgary, Calgary, AB, Canada

Source: Methods in Molecular Biology Published:2020


Abstract

Magnetic nanoparticles have demonstrated considerable capacity for theranosis purposes due to their unique characteristics, including magnetic properties, comparable size to biomolecules, favorable conjugations of drugs and biomolecules, ability to labeling, and capability of sensing, separation, detection, and targeted drug delivery. They could be exploited in magnetic resonance imaging as the contrast agents and also warmed as exposed to an external magnetic AC field that could be applied in hyperthermia. Here, progresses and advances in the strategy and assembly of fluorescent magnetic nanoparticles are presented for stem cell tracing and drugs/biomolecules targeting into cells. © 2019, Springer Science+Business Media New York.
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