Stem Cell Tracing Through Mr Molecular Imaging Publisher



Yahyapour R¹ ; Farhood B² ; Graily G³ ; Rezaeyan A⁴ ; Rezapoor S⁵ ; Abdollahi H⁴ ; Cheki M⁶ ; Amini P⁵ ; Fallah H⁷ ; Najafi M⁸ ; Motevaseli E⁹ Show Affiliations
Source: Tissue Engineering and Regenerative Medicine Published:2018

Abstract

Stem cell therapy opens a new window in medicine to overcome several diseases that remain incurable. It appears such diseases as cardiovascular disorders, brain injury, multiple sclerosis, urinary system diseases, cartilage lesions and diabetes are curable with stem cell transplantation. However, some questions related to stem cell therapy have remained unanswered. Stem cell imaging allows approval of appropriated strategies such as selection of the type and dose of stem cell, and also mode of cell delivery before being tested in clinical trials. MRI as a non-invasive imaging modality provides proper conditions for this aim. So far, different contrast agents such as superparamagnetic or paramagnetic nanoparticles, ultrasmall superparamagnetic nanoparticles, fluorine, gadolinium and some types of reporter genes have been used for imaging of stem cells. The core subject of these studies is to investigate the survival and differentiation of stem cells, contrast agent’s toxicity and long term following of transplanted cells. The promising results of in vivo and some clinical trial studies may raise hope for clinical stem cells imaging with MRI. © 2018, The Korean Tissue Engineering and Regenerative Medicine Society and Springer Science+Business Media B.V., part of Springer Nature.