Clonal Expansion of Environmental Triazole Resistant Aspergillus Fumigatus in Iran

Clonal Expansion of Environmental Triazole Resistant Aspergillus Fumigatus in Iran Publisher

Ahangarkani F^{1, 2} ; Badali H^{3, 4} ; Abbasi K⁵ ; Nabili M⁶ ; Khodavaisy S⁷ ; De Groot T¹ ; Meis JF^{1, 8, 9}

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1. Department of Medical Microbiology and Infectious Diseases, Canisius-Wilhelmina Hospital, Nijmegen, 6532 SZ, Netherlands
2. Antimicrobial Resistance Research Center, Communicable Diseases Institute, Mazandaran University of Medical Sciences, Sari, 4815733971, Iran
3. Invasive Fungi Research Center, Communicable Diseases Institute, Mazandaran University of Medical Sciences, Sari, 4815733971, Iran
4. Fungus Testing Laboratory, Department of Pathology and Laboratory Medicine, University of Texas Health Science Center at San Antonio, San Antonio, 78229, TX, United States
5. Department of Microbiology, Zanjan Branch, Islamic Azad University, Zanjan, 4515658145, Iran
6. Department of Medical Sciences, Sari Branch, Islamic Azad University, Sari, 4815733971, Iran
7. Department of Medical Parasitology and Mycology, School of Public Health, Tehran University of Medical Sciences, Tehran, 1411734143, Iran
8. ECMM Excellence Center for Medical Mycology, Centre of Expertise in Mycology Radboudumc, Canisius-Wilhelmina Hospital, Nijmegen, 6532 SZ, Netherlands
9. Federal University of Parana, Curitiba, 80010, Parana, Brazil

Source: Journal of Fungi Published:2020

Abstract

Azole-resistance in Aspergillus fumigatus is a worldwide medical concern complicating the management of aspergillosis (IA). Herein, we report the clonal spread of environmental triazole resistant A. fumigatus isolates in Iran. In this study, 63 A. fumigatus isolates were collected from 300 compost samples plated on Sabouraud dextrose agar supplemented with itraconazole (ITR) and voriconazole (VOR). Forty-four isolates had the TR34 /L98H mutation and three isolates a TR46 /Y121F/T289A resistance mechanism, while two isolates harbored a M172V substitution in cyp51A. Fourteen azole resistant isolates had no mutations in cyp51A. We found that 41 out of 44 A. fumigatus strains with the TR34 /L98H mutation, isolated from compost in 13 different Iranian cities, shared the same allele across all nine examined microsatellite loci. Clonal expansion of triazole resistant A. fumigatus in this study emphasizes the importance of establishing antifungal resistance surveillance studies to monitor clinical Aspergillus isolates in Iran, as well as screening for azole resistance in environmental A. fumigatus isolates. © 2020 by the authors. Licensee MDPI, Basel, Switzerland.

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Sadegh Khodavaisy (13)

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Style	Citing Format
MLA	Ahangarkani F, et al.. "Clonal Expansion of Environmental Triazole Resistant Aspergillus Fumigatus in Iran." Journal of Fungi, vol. 6, no. 4, 2020, pp. 1-9.
APA	Ahangarkani F, Badali H, Abbasi K, Nabili M, Khodavaisy S, De Groot T, Meis JF (2020). Clonal Expansion of Environmental Triazole Resistant Aspergillus Fumigatus in Iran. Journal of Fungi, 6(4), 1-9.
Chicago	Ahangarkani F, Badali H, Abbasi K, Nabili M, Khodavaisy S, De Groot T, Meis JF. "Clonal Expansion of Environmental Triazole Resistant Aspergillus Fumigatus in Iran." Journal of Fungi 6, no. 4 (2020): 1-9.
Harvard	Ahangarkani F et al. (2020) 'Clonal Expansion of Environmental Triazole Resistant Aspergillus Fumigatus in Iran', Journal of Fungi, 6(4), pp. 1-9.
Vancouver	Ahangarkani F, Badali H, Abbasi K, Nabili M, Khodavaisy S, De Groot T, et al.. Clonal Expansion of Environmental Triazole Resistant Aspergillus Fumigatus in Iran. Journal of Fungi. 2020;6(4):1-9.
BibTex	@article{ author = {Ahangarkani F and Badali H and Abbasi K and Nabili M and Khodavaisy S and De Groot T and Meis JF}, title = {Clonal Expansion of Environmental Triazole Resistant Aspergillus Fumigatus in Iran}, journal = {Journal of Fungi}, volume = {6}, number = {4}, pages = {1-9}, year = {2020} }
RIS	TY - JOUR AU - Ahangarkani F AU - Badali H AU - Abbasi K AU - Nabili M AU - Khodavaisy S AU - De Groot T AU - Meis JF TI - Clonal Expansion of Environmental Triazole Resistant Aspergillus Fumigatus in Iran JO - Journal of Fungi VL - 6 IS - 4 SP - 1 EP - 9 PY - 2020 ER -

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