Tehran University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
Does Oxidative Stress Cause Insulin Resistance in Women With Polycystic Ovary Syndrome? Publisher



Zafarizangeneh F1
Authors
Show Affiliations
Authors Affiliations
  1. 1. Vali Asr Reproductive Health Research Center, Imam Hospital, Tehran University of Medical Sciences, Tehran, Iran

Source: Journal of Isfahan Medical School Published:2020


Abstract

Background: Polycystic ovary syndrome (PCOS), with a prevalence of 4-12 percent, is the most common endocrine-metabolic disorder in reproductive age of women. Reproductive disorders in women with PCO include hyperinsulinemia, hyperandrogenism, chronic anovulation, and infertility. The purpose of this paper was to review and confirm the important role of oxidative stress in creating insulin resistance in this syndrome. Methods: All relevant information was collected through databases such as PubMed and Google Scholar, which was extracted from a total of 100 articles between 1989-2020. Today, the assessment of oxidative stress in women with PCO is performed using circulatory markers such as malondialdehyde (MDA), superoxide dismutase (SOD), and glutathione peroxidase (GPX). Findings: Insulin resistance can be associated with the conditions of oxidative stress in women with PCO. Therefore, obtaining oxidative stress index can be considered valuable, and represent the occurrence of metabolic disorders in this syndrome. Conclusion: Oxidative stress can play a key role in insulin resistance. Therefore, the oxidative stress index can help to understand unknown metabolic causes of this syndrome. © 2020 Isfahan University of Medical Sciences(IUMS). All rights reserved.
Related Docs
View other Related Docs
1. Effect of Alpha-2 Adenoceptor Inhibitors on the Growth of Ovarian Follicles in Patients With Polycystic Ovary Syndrome, Tehran University Medical Journal (2016)
2. The Therapeutic Effects and Mechanisms of Action of Resveratrol on Polycystic Ovary Syndrome: A Comprehensive Systematic Review of Clinical, Animal and in Vitro Studies, Clinical and Experimental Pharmacology and Physiology (2022)
3. Changes in Expression of Alpha-1, 2 and Β-2 Adenoidal Receptor Gene in Cumulus Cells of Infertile Women With Polycystic Ovary Syndrome (Ivf Candidate) and Effect of Clonidine on It Situations, Iranian Journal of Obstetrics# Gynecology and Infertility (2019)
4. Polycystic Ovary Syndrome and Sympathoexcitation: Management of Stress and Lifestyle, Journal of Biology and Today's World (2017)
5. Expression of Adr-Α1, 2 and Adr-Β2 in Cumulus Cell Culture of Infertile Women With Polycystic Ovary Syndrome and Poor Responder Who Are a Candidate for Ivf: The Novel Strategic Role of Clonidine in This Expression, Journal of Receptors and Signal Transduction (2021)
6. Psychoneuromedulator Role of Corticotrophin Releasing Hormone in Pcos, Tehran University Medical Journal (2016)
7. The Probiotic Supplementation Reduced Inflammation in Polycystic Ovary Syndrome: A Randomized, Double-Blind, Placebo-Controlled Trial, Journal of Functional Foods (2018)
8. Are Crh & Ngf As Psychoneuroimmune Regulators in Women With Polycystic Ovary Syndrome?, Gynecological Endocrinology (2017)
Experts (# of related papers)
View all Related Experts
Fardin Amidi (6)
Mohammad Abdollahi (3)
Other Related Docs
9. The Effect of Metabolic Syndrome on Controlled Ovarian Stimulation Outcome in Infertile Women With Polycystic Ovary Syndrome Undergoing Assisted Reproductive Technology Cycles, Archives of Endocrinology and Metabolism (2023)
10. Ameliorative Effect of Chitosan-Propolis Nanoparticles on the Estradiol Valerate-Induced Polycystic Ovary Syndrome Model, Jundishapur Journal of Natural Pharmaceutical Products (2023)
11. A Low-Grade Chronic Inflammation in Polycystic Ovary Syndrome: Role of Interleukin-1 Alpha, 1 Beta, 17A and Tnfα, Iranian Journal of Obstetrics# Gynecology and Infertility (2015)
12. Polycystic Ovary Syndrome and Circulating Inflammatory Markers, International Journal of Reproductive BioMedicine (2017)
13. Antioxidant Supplementations Ameliorate Pcos Complications: A Review of Rcts and Insights Into the Underlying Mechanisms, Journal of Assisted Reproduction and Genetics (2021)
14. Assessing the Effect of Mitoq10 and Vitamin D3 on Ovarian Oxidative Stress, Steroidogenesis and Histomorphology in Dhea Induced Pcos Mouse Model, Heliyon (2020)
15. Dual Targeting of Tnf- Α and Free Radical Toxic Stress As a Promising Strategy to Manage Experimental Polycystic Ovary, Pharmaceutical Biology (2016)
16. Type 2 Diabetes Mellitus and Alzheimer's Disease: A Review of the Potential Links, Current Diabetes Reviews (2022)
17. The Knowledge Domain and Emerging Trends in the Infertility Field: A 67-Year Retrospective Study, Health Care for Women International (2024)
18. The Effect of Oligopin Supplementation on Hormonal and Metabolic Profiles in the Polycystic Ovary Syndrome: A Randomized Controlled Trial, Frontiers in Endocrinology (2020)
19. Resveratrol Treatment in Patients With Polycystic Ovary Syndrome Decreased Pro-Inflammatory and Endoplasmic Reticulum Stress Markers, American Journal of Reproductive Immunology (2020)
20. Effect of Ramadan Fasting on Stress Neurohormones in Women With Polycystic Ovary Syndrome, Journal of Family and Reproductive Health (2015)
21. Association of Serum Selenium and Selenoprotein P With Oxidative Stress Biomarkers in Patients With Polycystic Ovary Syndrome, Biological Trace Element Research (2024)
22. Quercetin and Polycystic Ovary Syndrome; Inflammation, Hormonal Parameters and Pregnancy Outcome: A Randomized Clinical Trial, American Journal of Reproductive Immunology (2023)
23. Risk of Endometrial, Ovarian, and Breast Cancers in Women With Polycystic Ovary Syndrome: A Systematic Review and Meta-Analysis, International Journal of Reproductive BioMedicine (2022)
24. Zinc Status and Polycystic Ovarian Syndrome: A Systematic Review and Meta-Analysis, Journal of Trace Elements in Medicine and Biology (2019)
25. Ace I/D Gene Polymorphisms and Polycystic Ovary Syndrome Manifestations, Journal of Diabetes and Metabolic Disorders (2023)
26. Comparing Life Style of Patients With Polycystic Ovary Syndrome and Normal Women, Tehran University Medical Journal (2018)
27. Polycystic Ovary Syndrome Is a Risk Factor for Diabetes and Prediabetes in Middle-Aged But Not Elderly Women: A Long-Term Population-Based Follow-Up Study, Fertility and Sterility (2017)
28. Astaxanthin Treatment Ameliorates Er Stress in Polycystic Ovary Syndrome Patients: A Randomized Clinical Trial, Scientific Reports (2023)
29. The Modulating Effects of Astaxanthin on Apoptosis in Women With Polycystic Ovarian Syndrome: A Randomized Clinical Trial, Avicenna Journal of Phytomedicine (2024)
30. The Effect of Chromium Intake on Oxidative Stress Parameters: A Systematic Review and Meta-Analysis, Journal of Trace Elements in Medicine and Biology (2022)
31. Cellular and Molecular Mechanisms of Pentoxifylline's Beneficial Effects in Experimental Polycystic Ovary, Theriogenology (2015)
32. Evaluation of Lipid Ratios and Triglyceride-Glucose Index As Risk Markers of Insulin Resistance in Iranian Polycystic Ovary Syndrome Women, Lipids in Health and Disease (2020)
33. Polycystic Ovary Syndrome: A Comprehensive Review of Pathogenesis, Management, and Drug Repurposing, International Journal of Molecular Sciences (2022)
34. The Potential Relationship Between Different Human Female Reproductive Disorders and Sperm Quality in Female Genital Tract, Reproductive Sciences (2022)
35. Potential Roles of Genistein in Polycystic Ovary Syndrome: A Comprehensive Systematic Review, European Journal of Pharmacology (2022)
36. Cardiac Function and Tolerance to Ischemia/Reperfusion Injury in a Rat Model of Polycystic Ovary Syndrome During the Postmenopausal Period, Life Sciences (2020)
37. Potential Roles of Carnitine in Patients With Polycystic Ovary Syndrome: A Systematic Review, Gynecological Endocrinology (2019)
38. The Risk of Metabolic Syndrome in Polycystic Ovary Syndrome: A Systematic Review and Meta-Analysis, Clinical Endocrinology (2018)
39. The Influences of Vitamin D and Omega-3 Co-Supplementation on Clinical, Metabolic and Genetic Parameters in Women With Polycystic Ovary Syndrome, Journal of Affective Disorders (2018)
40. The Role of Melatonin in Polycystic Ovary Syndrome: A Review, International Journal of Reproductive BioMedicine (2019)
41. Evaluation of Angiopoietin-Like Protein 3 (Angptl3) Levels in Polycystic Ovary Syndrome, Life Sciences (2020)
42. The Hormone-Sensitive Lipase C-60G Polymorphism Is Correlated With Recurrent Spontaneous Abortion in Women With Polycystic Ovary Syndrome, Gene Reports (2023)
43. Metabolic Syndrome and Its Components Among Women With Polycystic Ovary Syndrome: A Systematic Review and Meta-Analysis, Journal of Cardiovascular and Thoracic Research (2018)
44. Dietary Carbohydrate Composition Is Associated With Polycystic Ovary Syndrome: A Case–Control Study, Journal of Human Nutrition and Dietetics (2017)
45. Quercetin As a Possible Complementary Therapy in Multiple Sclerosis: Anti-Oxidative, Anti-Inflammatory and Remyelination Potential Properties, Heliyon (2023)
46. Omega-3 Fatty Acids Supplementation and Oxidative Stress Parameters: A Systematic Review and Meta-Analysis of Clinical Trials, Pharmacological Research (2019)
47. Assessment the Health-Related Quality of Life in Women With Polycystic Ovary Syndrome, Tehran University Medical Journal (2020)
48. Oxidative Stress As a Possible Mechanism of Statin-Induced Myopathy, Inflammopharmacology (2018)
49. Polycystic Ovary Syndrome and Its Impact on Iranian Women's Quality of Life: A Population-Based Study, BMC Women's Health (2018)
50. Evaluation of Cardiac Hemodynamic Parameters Following Ischemia-Reperfusion Injury in a Rat Model of Polycystic Ovary Syndrome, Journal of Mazandaran University of Medical Sciences (2020)