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Effects of Green Coffee Supplementation on Paraoxonase-1 Activity and Malondialdehyde Levels in Iranian Women With Polycystic Ovary Syndrome: A Randomized Clinical Trial Publisher



Ildarabadi A1 ; Vahiddastjerdi M2 ; Ghorbanpour M3 ; Mousavi A1 ; Meshkani M1 ; Yekaninejad M4 ; Saedisomeolia A5, 6
Authors
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Authors Affiliations
  1. 1. Department of Nutrition Science, Science and Research Branch, Faculty of Medical Science and Technology, Islamic Azad University, Tehran, Iran
  2. 2. Department of Obstetrics and Gynecology, School of Medicine, Tehran University of Medical Science, Tehran, Iran
  3. 3. University Research and Development Center, Tehran University of Medical Sciences, Tehran, Iran
  4. 4. Department of Epidemiology and Biostatistics, School of Public Health, Tehran University of Medical Science, Tehran, Iran
  5. 5. Higher Education College of Health Sciences, Education Centre of Australia, Parramatta, NSW, Australia
  6. 6. School of Human Nutrition, McGill University, Montreal, QC, Canada

Source: Osong Public Health and Research Perspectives Published:2024


Abstract

Objectives: Polycystic ovary syndrome (PCOS) is a common, heterogeneous clinical syndrome affecting women. Investigating oxidative stress in women is crucial, as it is linked to insulin resistance and endothelial dysfunction. Chlorogenic acid, a bioactive component found in green coffee, has numerous documented health benefits. This study aimed to assess the beneficial effects of green coffee consumption on paraoxonase-1 (PON-1) activity and malondialdehyde (MDA) levels in women with PCOS. Methods: This study was a double-blind randomized clinical trial that included 44 patients with PCOS. Participants were randomly assigned to either the intervention or control group. For 6 weeks, the intervention group (n=22) received 400 mg of green coffee supplements, while the control group (n=22) received 400 mg of a starch-based placebo. Anthropometric indices, dietary assessments, and physical activity levels were evaluated before and after the 6-week intervention period. Additionally, blood samples were collected for laboratory analysis. Results: Supplementation with green coffee increased PON-1 levels by 3.5 units, a significant finding (p=0.038). Additionally, the intake of green coffee supplements significantly reduced blood cholesterol levels by 18.8 units (p=0.013) and triglyceride levels by 6.1 units (p=0.053). However, no significant differences were observed in the levels of MDA, high-density lipoprotein, low-density lipoprotein, fasting blood sugar, insulin, or homeostatic model assessment of insulin resistance as a result of the intervention. Conclusion: Supplementation with green coffee alters PON-1 activity and cholesterol levels in women with PCOS. However, it has no significant impact on MDA levels or glycemic status. © 2024 Korea Disease Control and Prevention Agency.
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