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Potential Use of Angiotensin Receptor Blockers in Skin Pathologies Publisher



Hedayatyanfard K1, 2 ; Khalili A1 ; Karim H2, 3 ; Nooraei S4 ; Khosravi E5 ; Haddadi NS6 ; Dehpour AR7 ; Bayat G1
Authors
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Authors Affiliations
  1. 1. Department of Physiology, Pharmacology and Medical Physic, School of Medicine, Alborz University of Medical Sciences, Karaj, Iran
  2. 2. Cardiovascular Research Center, Alborz University of Medical Sciences, Karaj, Iran
  3. 3. Department of Cardiology, School of Medicine, Alborz University of Medical Sciences, Karaj, Iran
  4. 4. Student of School of Veterinary Medicine, Faculty of Veterinary Medicine, University of Shahrekord, Shahrekord, Iran
  5. 5. Department of Veterinary Surgery, Science and Research Branch, Islamic Azad University, Tehran, Iran
  6. 6. Department of Dermatology, University of Massachusetts School of Medicine, Worchester, MA, United States
  7. 7. Department of Pharmacology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran

Source: Iranian Journal of Basic Medical Sciences Published:2023


Abstract

Renin-angiotensin system (RAS) components such as angiotensin II, angiotensin receptors (AT1R and AT2R), and angiotensin-converting enzyme (ACE) are expressed in different cell types of the skin. Through AT1R, angiotensin II increases proinflammatory cytokines contributing to fibrosis, angiogenesis, proliferation, and migration of immune cells to the skin. In contrast, AT2R suppresses the effects mentioned above. Many studies show that angiotensin receptor blockers (ARBs) and angiotensin-converting enzymes (ACEi) reduce the proinflammatory cytokines and fibrogenic factors including transforming growth factor β (TGF-β), Connective tissue growth factor (CTGF), and IL-6. This review article provides a detailed research study on the implications of ARBs in wound healing, hypertrophic scar, and keloids. We further discuss the therapeutic potentials of ARBs in autoimmune and autoinflammatory skin diseases and cancer, given their anti-fibrotic and anti-inflammatory effects. © 2023 Mashhad University of Medical Sciences. All rights reserved.
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