Role of Cultured Skin Fibroblasts in Regenerative Dermatology Publisher Pubmed



Nilforoushzadeh MA^{1, 2} ; Khodaverdi Darian E^{3, 4} ; Afzali H¹ ; Amirkhani MA¹ ; Razzaghi M⁵ ; Naser R⁶ ; Amiri AB¹ ; Alimohammadi A⁷ ; Nikkhah N¹ ; Zare S¹ Show Affiliations
Source: Aesthetic Plastic Surgery Published:2022

Abstract

Abstract: The skin, as the largest organ, covers the entire outer part of the body, and since this organ is directly exposed to microbial, thermal, mechanical and chemical damage, it may be destroyed by factors such as acute trauma, chronic wounds or even surgical interventions. Cell therapy is one of the most important procedures to treat skin lesions. Fibroblasts are cells that are responsible for the synthesis of collagen, elastin, and the organization of extracellular matrix (ECM) components and have many vital functions in wound healing processes. Today, cultured autologous fibroblasts are used to treat wrinkles, scars, wounds and subcutaneous atrophy. The results of many studies have shown that fibroblasts can be effective and beneficial in the treatment of skin lesions. On the other hand, skin substitutes are used as a regenerative model to improve and regenerate the skin. The use of these alternatives, restorative medicine and therapeutic cells such as fibroblasts has tremendous potential in the treatment of skin diseases and can be a new window for the treatment of diseases with no definitive treatment. No Level Assigned: This journal requires that authors assign a level of evidence to each submission to which Evidence-Based Medicine rankings are applicable. This excludes Review Articles, Book Reviews, and manuscripts that concern Basic Science, Animal Studies, Cadaver Studies, and Experimental Studies. For a full description ofthese Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors www.springer.com/00266. © 2022, Springer Science+Business Media, LLC, part of Springer Nature and International Society of Aesthetic Plastic Surgery.