Clinical Application of Biomaterials in Orbital Implants: A Systematic Review Publisher Pubmed



Sadeghi S¹ ; Pezeshgi S² ; Sadeghi R² ; Bayan N^{2, 3} ; Farrokhpour H² ; Amanollahi M² ; Bereimipour A⁴ ; Abolghasemi Mahani A⁵
Source: International Ophthalmology Published:2024

Abstract

Purpose: Various materials have been proposed for reconstructing orbital fractures. The materials used must meet certain criteria to ensure their suitability for restoring the structure and function of the organ. These criteria include biocompatibility, ease of application, non-toxicity, hypo-allergenicity, and non-carcinogenicity. In this study, we systematically reviewed the studies regarding the biomaterials in orbital implants and their clinical application. Methods: A comprehensive search across various databases, including PubMed, Scopus, EMBASE, Cochrane Library, and Web of Science, was conducted until April 10th, 2023. After retrieving the search results and eliminating duplicates, final studies were included after screening through defined criteria. Human and animal studies assessing the clinical application of biomaterials in orbital implants were included. The quality of the case series and controlled intervention studies were evaluated using the NIH tool, and for animal studies, the risk of bias was assessed using SYRCLE's tool. Results: Seventeen studies were included according to defined criteria. These studies aimed to explore the clinical application of biomaterials and examine the associated complications in orbital implants. Conclusion: We found that using biomaterials did not result in elevated intraocular pressure (IOP). However, we did observe certain complications, with infection, residual diplopia, and enophthalmos being the most frequently reported issues. © The Author(s), under exclusive licence to Springer Nature B.V. 2024.