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Role of T Follicular Helper Cells in Autoimmune Rheumatic Diseases: A Systematic Review on Immunopathogenesis and Response to Treatment Publisher Pubmed



Mohammad Piri S1 ; Amin Habibi M2 ; Shool S3 ; Khazaeli Najafabadi M1 ; Ahmadpour S4 ; Alemi F5 ; Aria Nejadghaderi S3, 6 ; Shokri P3 ; Abdi M7 ; Asghari N7 ; Amir Asefagah S8 ; Tavakolpour S9
Authors
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Authors Affiliations
  1. 1. Department of Pathology, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran
  2. 2. Department of Neurosurgery, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran
  3. 3. Faculty of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  4. 4. Patient Safety Research Center, Clinical Research Institute, Urmia University of Medical Sciences, Urmia, Iran
  5. 5. School of Medicine, Mazandaran University of Medical Sciences, Sari, Iran
  6. 6. Systematic Review and Meta-analysis Expert Group (SRMEG), Universal Scientific Education and Research Network (USERN), Tehran, Iran
  7. 7. Student Research Committe, Faculty of Medicine, North Khorasan University of Medical Sciences, Bonjnurd, Iran
  8. 8. Student Research Committee, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
  9. 9. Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, United States

Source: Human Immunology Published:2024


Abstract

Background: T follicular helper (Tfh) cells are a subdivision of T helper cells involved in antigen-specific B cell immunity. Tfh cells play an essential role in the interaction of T cells/B cells in the germinal centers (GC), and dysregulation of Tfh actions can offer pathogenic autoantibody formation and lead to the development of autoimmune diseases. This study seeks to evaluate changes in Tfh frequency and its related cytokines in autoimmune disease, its association with disease phase, severity, prognosis, and the effect of immunosuppressive treatment on the Tfh population. Method: The study adhered to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) 2020 Statement. Electronic databases, including PubMed, Scopus, Web of Science, and Embase, were systematically searched for potentially eligible studies up to January 1, 2024. Results: We identified 4998 articles in the initial search, from which 1686 similar titles were removed. A total of 3312 articles were initially screened, and 3051 articles were excluded by title/abstract screening. A total of 261 studies were considered for full-text assessment, and 205 articles were excluded by reason. Finally, a total of 56 studies were included in our review. Conclusion: The population of Tfh cells is generally higher in autoimmune diseases versus Health control. Moreover, the number of Tfh cells is associated with the disease severity and can be considered for determining the prognosis of studies. Also, peripheral blood circulating Tfh (cTfh) cells are an available sample that can be used as an indicator for diagnosing diseases. © 2024 American Society for Histocompatibility and Immunogenetics
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