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Are Egfr Monoclonal Antibodies Associated With Clinical Benefits in Patients With Glioma: A Systematic Review, Meta-Analysis, and Specific Analysis on Glioblastoma and Diffuse Intrinsic Pontine Glioma Publisher Pubmed



Habibi MA1 ; Rashidi F2 ; Gharedaghi H3 ; Fathi Tavani S2 ; Farzalizadeh H2 ; Shahir Eftekhar M4 ; Bahri A5 ; Mohammadzadeh I6 ; Hajikarimloo B7
Authors
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Authors Affiliations
  1. 1. Department of Neurosurgery, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran
  2. 2. School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
  3. 3. School of Medicine, Zanjan University of Medical Science, Zanjan, Iran
  4. 4. Department of Surgery, School of Medicine, Shahid Beheshti Hospital, Qom University of Medical Sciences, Qom, Iran
  5. 5. Student Research Committee, School of Medicine, Iran University of Medical Sciences, Tehran, Iran
  6. 6. Skull Base Research Center, Loghman-Hakim Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  7. 7. Department of Neurological Surgery, University of Virginia, Charlottesville, VA, United States

Source: Neurosurgical Review Published:2025


Abstract

Glioma is one of the most common CNS malignancies with a high mortality rate. Overexpression of endothelial growth factor receptor (EGFR) has been suspected to play a critical role in the pathology of gliomas. This study aims to investigate the effectiveness of anti-EGFR monoclonal antibodies against glioma, specifically for glioblastoma and diffuse intrinsic pontine glioma. This Systematic review and meta-analysis was conducted according to The Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guideline. The search used the relevant keywords in four databases, including PubMed, Scopus, Web of Science, and Embase, until December 25th, 2023. All statistical analysis was done by STATA v.17. A total of 29 studies were included. A meta-analysis revealed that overall response was 34% (95%CI: 19-51%), complete response was 14% (95%CI: 3-24%), partial response was 13% (95% CI: 8-17%), progressive disease rate was 33% (95%CI: 24-43%), and stable disease rate was 29% (95%CI: 22-36%). In addition, the pooled 6-month progression-free survival (PFS) rate was 48% (95% CI: 33-62%), 1-year PFS was 25% (95%CI: 14-36%), 18-month PFS was 17% (95%CI: -5-39%), and 2-year PFS was 14% (95%CI: 3-25%). The 6-month overall survival (OS) was 82% (95%CI: 69-96%), 1-year OS was 61% (95%CI: 50-71%), 18-months OS was 39% (95%CI: 25 − 53%), and 2-year OS was 24% (95%CI: 15-33%). EGFR inhibitors benefit PFS, OS, and radiologic response in patients with different types of gliomas. Clinicians should consider them an attractive option for treating gliomas. © The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature 2025.