Role of Rare Immune Cells in Common Variable Immunodeficiency Publisher Pubmed



Soltani M¹ ; Rezaei M¹ ; Fekrvand S² ; Ganjalikhanihakemi M^{1, 3} ; Abolhassani H^{2, 4, 5} ; Yazdani R^{2, 6, 7} Show Affiliations
Source: Pediatric Allergy and Immunology Published:2022

Abstract

Common variable immunodeficiency disorder (CVID) is a heterogeneous disorder and the most common symptomatic antibody deficiency disease characterized with hypogammaglobulinemia and a broad range of clinical manifestations. Multiple genetic, epigenetic, and immunological defects are involved in the pathogenesis of CVID. These immunological defects include abnormalities in the number and/or function of B lymphocytes, T lymphocytes, and other rare immune cells. Although some immune cells have a relatively lower proportion among total immune subsets in the human body, they could have important roles in the pathogenesis of immunological disorders like CVID. To the best of our knowledge, this is the first review that described the role of rare immune cells in the pathogenesis and clinical presentations of CVID. © 2021 EAACI and John Wiley and Sons A/S. Published by John Wiley and Sons Ltd.