Tehran University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
Celiac Disease Seropositivity in Dilated Cardiomyopathy Patients and Correlation With Ejection Fraction Publisher



Rashidinia A1 ; Bozorgi A2 ; Abdollahi A3 ; Naserghandi A4 ; Ataeinia B5 ; Allameh SF1
Authors
Show Affiliations
Authors Affiliations
  1. 1. Department of Gastroenterology, Tehran University of Medical Sciences, Tehran, Iran
  2. 2. Tehran Heart Center, Tehran University of Medical Sciences, Tehran, Iran
  3. 3. Department of Pathology, Tehran University of Medical Sciences, Tehran, Iran
  4. 4. Student Research Committee, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  5. 5. Athinoula A Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, MA, United States

Source: Journal of Iranian Medical Council Published:2022


Abstract

Background: Recent evidence suggests a connection between celiac disease and dilated cardiomyopathy. Herein, we serologically screened for celiac in dilated cardiomyopathy patients and investigated its correlation with ejection fraction. Methods: We selected 123 cardiomyopathy patients. Patients were screened for celiac, using anti-tissue transglutaminase (ATA), anti-gliadin (AGA), and anti-endomysial (EMA) immunoglobulin type A (IgA) antibodies. Total IgA levels were also measured. Results: Of 123 patients, 3 were EMA positive (2.4%), 4 were AGA positive (3.3%) and 5 were ATA positive (4.1%). EMA positive patients had significantly lower EF values compared to EMA negative patients (35±5 vs. 46.52±9.21, p-value: 0.034). Similar results were observed for AGA (32.5±14.34 vs. 46.7±8.8, p-value: 0.002), but not for either ATA positivity (40±10 vs. 46.5±9.21, p-value: 0.126) or IgA deficiency (50±5 vs. 46.14±9.37, p-value: 0.480). No significant difference was observed in the age and gender of seropositive patients compared to seronegative. Conclusion: We observed a higher prevalence of celiac seropositivity among dilated cardiomyopathy patients compared to the general population. EMA and AGA positive patients had significantly lower ejection fractions compared to their negative counterparts. Copyright 2022, Journal of Iranian Medical Council. All rights reserved.
Related Docs
1. Extra Intestinal Manifestations of Celiac Disease and Associated Disorders, International Journal of Celiac Disease (2017)
2. Is It Necessary to Screen for Celiac Disease in Adult Idiopathic Osteoporosis?, Gastroenterology and Hepatology from Bed to Bench (2015)
3. Pitfalls in Estimation of Celiac Disease Prevalence Using Serology: A Cross-Sectional Study, Govaresh (2017)
4. Prevalence of Celiac Disease Among the Iranian Population: A Systematic Review and Meta-Analysis of Observational Studies, Turkish Journal of Gastroenterology (2016)
Experts (# of related papers)
View all Related Experts
Reza Malekzadeh (1)
Abbasali Keshtkar (1)