Non-Celiac Gluten Sensitivity As a Rare Cause of Growth Retardation in Children: A Case Series Study Publisher



Saneifard H¹ ; Sheikhy A² ; Karbasian F³ ; Eslamian G⁴ ; Shakiba M¹ ; Babaie D⁴ Show Affiliations
Source: Gastroenterology and Hepatology from Bed to Bench Published:2021

Abstract

Aim: Herein, we present five children and adolescents with a final diagnosis of non-celiac gluten sensitivity (NCGS). Background: Non-celiac gluten sensitivity (NCGS) is a condition characterized by gastrointestinal and extra-intestinal symptoms triggered by ingestion of gluten-containing compounds, e.g., wheat, rye, and barley, in subjects without celiac disease or wheat allergy. Methods: Demographic characteristics, clinical manifestations, serum biomarkers and skin prick test were evaluated. Patient data was also recorded after they followed a gluten-free diet (GFD). Height and weight were measured, and all patients were examined 6 months after following the suggested GFD. Results: All patients had failure to thrive and abdominal pain. Clinical symptoms were reduced, and significant weight and height gains were detected after 1 month of following a gluten-free diet. Conclusion: The relationship between failure to thrive (FTT) and NCGS is still unknown; hence, NCGS may be one of the main causes of FTT which can be prevented by gluten-free diets. © 2021 RIGLD.