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Precision Medicine in Cardiovascular Disease Practice Publisher



Sheikhy A1, 2, 3 ; Fallahzadeh A1, 2, 3 ; Meybodi HRA4 ; Hosseini K1, 2
Authors
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Authors Affiliations
  1. 1. Tehran Heart Center, Cardiovascular Diseases Research Institute, Tehran University of Medical Sciences, Tehran, Iran
  2. 2. Cardiac Primary Prevention Research Center, Cardiovascular Diseases Research Institute, Tehran University of Medical Sciences, Tehran, Iran
  3. 3. Non-Communicable Disease Research Center, Endocrinology and Metabolism Population Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran
  4. 4. Personalized Medicine Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran

Source: Precision Medicine in Clinical Practice Published:2022


Abstract

Cardiovascular diseases (CVDs) as the leading cause of death and morbidity worldwide, have a substantial genetic basis. The personalized medicine (PM) concept tailors therapeutic and preventive strategies according to the genomic, epigenomic, and proteomic profiles of each individual. In the field of cardiology, PM can help cardiologists and health care providers to prevent adverse drug reactions (ADR) and select the best-individualized medication. In addition, a considerable number of cardiomyopathies, arrhythmias, and coronary artery disease (CAD) risk factors have also a genetic basis. In this chapter, we thoroughly reviewed the genetic background in the metabolism of important cardiovascular drugs such as warfarin, clopidogrel, and statins. Moreover, the cardinal role of genetic pathways in the occurrence of cardiomyopathies, arrhythmia, and CAD will be discussed. Finally, the ethical issues and prospective of PM were also reviewed to lighten all aspects of PM in cardiovascular medicine. © The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Nature Singapore Pte Ltd. 2022.
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