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Personalized Medicine in Cardiovascular Disease: Review of Literature Publisher



Sheikhy A1 ; Fallahzadeh A1 ; Aghaei Meybodi HR2 ; Hasanzad M3, 4 ; Tajdini M5 ; Hosseini K5
Authors
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Authors Affiliations
  1. 1. Research Department, Tehran Heart Center, Tehran University of Medical Sciences, Tehran, Iran
  2. 2. Endocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran
  3. 3. Personalized Medicine Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran
  4. 4. Medical Genomics Research Center, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran
  5. 5. Cardiology Department, Tehran Heart Center, Tehran University of Medical Sciences, Tehran, Iran

Source: Journal of Diabetes and Metabolic Disorders Published:2021


Abstract

Purpose: Personalized medicine (PM) is the concept of managing patients based on their characteristics, including genotypes. In the field of cardiology, advantages of PM could be found in the diagnosis and treatment of several conditions such as arrhythmias and cardiomyopathies; moreover, it may be beneficial to prevent adverse drug reactions (ADR) and select the best medication. Genetic background can help us in selecting effective treatments, appropriate dose requirements, and preventive strategies in individuals with particular genotypes. Method: In this review, we provide examples of personalized medicine based on human genetics for the most used pharmaceutics in cardiology, including warfarin, clopidogrel, and statins. We also review cardiovascular diseases, including coronary artery disease, arrhythmia, and cardiomyopathies. Conclusion: Genetic factors are as important as environmental factors and they should be tested and evaluated more in the future by improving in genetic testing tools. © 2021, Springer Nature Switzerland AG.
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