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Surgery-Induced Weight Loss and Changes in Hormonally Active Fibroblast Growth Factors: A Systematic Review and Meta-Analysis Publisher Pubmed



Hosseinzadeh A1 ; Roever L2 ; Alizadeh S3
Authors
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Authors Affiliations
  1. 1. School of Nursing and Midwifery, Iran University of Medical Sciences, Tehran, Iran
  2. 2. Department of Clinical Research, Federal University of Uberlandia, Uberlandia, Brazil
  3. 3. Department of Clinical Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences (TUMS), Tehran, Iran

Source: Obesity Surgery Published:2020


Abstract

This systematic review and meta-analysis was performed to investigate the possible changes of FGF-19 and FGF-21 after bariatric surgery (BS). Electronic databases including PubMed and Scopus were systematically searched up to February 2020 to identify pertinent studies. A total of 25 different studies were included. The overall pooled analysis identified that BS caused a significant increase in FGF-19, but had no significant effect on FGF-21. For FGF-19, this finding was supported in the subgroup analyses. For FGF-21, Roux-en-Y gastric bypass (RYGB) surgery significantly increased FGF-21 levels, whereas, in studies with follow-up duration ≥ 1 year, FGF-21 levels decreased significantly. BS reduces circulating concentration of FGF-19, but might increase FGF-21 after RYGB or decrease FGF-21 after ≥ 1 year. © 2020, Springer Science+Business Media, LLC, part of Springer Nature.
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