Tehran University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
Association Between Il7 Receptor Alpha (Il7ra) Gene Rs6897932 Polymorphism and the Risk of Multiple Sclerosis: A Meta-Regression and Meta-Analysis. Publisher Pubmed



Omraninava M1 ; Mehranfar S2, 3 ; Vahedi P4 ; Razi B5 ; Imani D6 ; Aslani S7 ; Feyzinia S8, 9
Authors
Show Affiliations
Authors Affiliations
  1. 1. Department of Infectious Disease, Faculty of Medical Sciences, Sari Branch, Islamic Azad University, Sari, Iran
  2. 2. Department of Genetics and Immunology, Faculty of Medicine, Urmia University of Medical Sciences, Urmia, Iran
  3. 3. Social Determinant of Health Research Center, Clinical Research Institute, Urmia University of Medical Sciences, Urmia, Iran
  4. 4. Department of anatomical sciences, Maragheh University of Medical Sciences, Maragheh, Iran
  5. 5. Department of Hematology, School of Medicine, Tarbiat Modares University, Tehran, Iran
  6. 6. Department of Immunology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran
  7. 7. Department of Immunology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
  8. 8. Tuberculosis and Lung Diseases Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
  9. 9. Rahat Breath and Sleep Research Center, Tabriz University of Medical Sciences, Tabriz, Iran

Source: Multiple Sclerosis and Related Disorders Published:2021


Abstract

Background: In this systematic review and meta-analysis, we aimed to find a consistent conclusion for the association between the interleukin 7 receptor alpha (IL7RA) gene rs6897932 single nucleotide polymorphism (SNP) and multiple sclerosis (MS) risk. Methods: Here, we performed a comprehensive systematic search in PubMed, Scopus, and Web of Science to find relevant studies published before November 2020 investigating the association between rs6897932 SNP and MS risk. In the pooled analysis, we determined the odds ratio (OR) and the corresponding 95% confidence interval (CI) for the association level between rs6897932 SNP and the risk of MS. Results: In the current meta-analysis 33 case-control studies (30 articles) containing 19351 patients and 21005 healthy controls certify the inclusion criteria. According to the pooled analysis, a statistically significant association of IL7RA gene rs6897932 SNP with MS risk was found across recessive model (OR= 0.84, 95% CI= 0.77-0.92, P< 0.001, FEM), allelic model (OR= 0.91, 95% CI= 0.85-0.99, P= 0. 02, REM), TT vs. CC model (OR= 0.79, 95% CI= 0.67-0.93, P= 0.005, REM). Moreover, the subgroup analysis based on the ethnicity indicated a negative significant association in Europeans; dominant model (OR= 0.88, 95% CI= 0.78-1.01, P= 0.06, REM), recessive model (OR= 0.79, 95% CI= 0.71-0.88, P< 0.001, REM), allelic model (OR= 0.88, 95% CI= 0.81-0.96, P= 0.003, REM), TT vs. CC model (OR= 0.74, 95% CI= 0.61-0.88, P<0.001, REM) models. Nonetheless, no significant association was detected in Asians and Americans. Conclusions: IL7RA gene rs6897932 SNP decreases MS susceptibility in overall population and Europeans. © 2020 Elsevier B.V.
Related Docs
View other Related Docs
1. Interleukin 7 Receptor Polymorphisms and the Risk of Multiple Sclerosis: A Meta-Analysis, Multiple Sclerosis and Related Disorders (2016)
2. Il-7Ra Association and Genotype-Dependent Severity and Response to Ifn-Β Therapy in Multiple Sclerosis, Acta Medica Iranica (2019)
3. Association of Il2ra and Multiple Sclerosis Risk: A Case Control, Systematic Review, and Meta-Analysis Study, Journal of the Neurological Sciences (2025)
4. Matrix Metalloproteinases (Mmps) Family Gene Polymorphisms and the Risk of Multiple Sclerosis: Systematic Review and Meta-Analysis, BMC Neurology (2020)
5. The Expression of Lnc-Il-7R Long Non-Coding Rna Dramatically Correlated With Soluble and Membrane-Bound Isoforms of Il-7Ra Gene in Multiple Sclerosis Patients, Neuroscience Letters (2017)
6. Association Between the Cyp1a1 Mspi Polymorphism and Risk of Head and Neck Cancer: A Meta-Analysis, Scientific Reports (2022)
7. Intestinal Parasites Among Intellectually Disabled Individuals in Iran: A Systematic Review and Meta-Analysis, Gut Pathogens (2021)
8. Metabolic Syndrome and Its Components Are Related to a Higher Risk for Albuminuria and Proteinuria: Evidence From a Meta-Analysis on 10,603,067 Subjects From 57 Studies, Diabetes and Metabolic Syndrome: Clinical Research and Reviews (2019)
Experts (# of related papers)
View all Related Experts
Sakineh Shab-Bidar (32)
Hamed Mohammadi (16)
Other Related Docs
9. Association Between Vitamin D Receptor (Vdr) Polymorphisms and the Risk of Multiple Sclerosis (Ms): An Updated Meta-Analysis, BMC Neurology (2019)
10. Does Bracing Control the Progression of Adolescent Idiopathic Scoliosis in Curves Higher Than 40°? a Systematic Review and Meta-Analysis, Asian Spine Journal (2023)
11. The Effects of Conjugated Linoleic Acid Supplementation on Liver Function Enzymes and Malondialdehyde in Adults: A Grade-Assessed Systematic Review and Dose-Response Meta-Analysis, Pharmacological Research (2022)
12. Association Between Maternal Exposure to Polycyclic Aromatic Hydrocarbons and Birth Anthropometric Outcomes: A Systematic Review and Meta-Analysis, Ecotoxicology and Environmental Safety (2024)
13. Relevance of Hmlh1-93G>A, 655A>G and 1151T>A Polymorphisms With Colorectal Cancer Susceptibility: A Meta-Analysis Based on 38 Case-Control Studies, Revista da Associacao Medica Brasileira (2018)
14. Effect of Serum Lipid Profile on the Risk of Breast Cancer: Systematic Review and Meta-Analysis of 1,628,871 Women, Journal of Clinical Medicine (2022)
15. Dysregulation of Micrornas Regulating Survivin in Cd4+ T Cells in Multiple Sclerosis, Multiple Sclerosis and Related Disorders (2020)
16. Surgery-Induced Weight Loss and Changes in Hormonally Active Fibroblast Growth Factors: A Systematic Review and Meta-Analysis, Obesity Surgery (2020)
17. Effect of Resveratrol on Inflammatory Cytokines: A Meta-Analysis of Randomized Controlled Trials, European Journal of Pharmacology (2021)
18. A Systematic Review, Meta-Analysis, Dose-Response, and Meta-Regression of the Effects of Acarbose Intake on Glycemic Markers in Adults, Journal of Diabetes and Metabolic Disorders (2023)
19. Global Prevalence of Asthma-Copd Overlap (Aco) in the General Population: A Systematic Review and Meta-Analysis, Respiratory Research (2019)
20. Potato Consumption and Risk of All Cause, Cancer and Cardiovascular Mortality: A Systematic Review and Dose-Response Meta-Analysis of Prospective Cohort Studies, Critical Reviews in Food Science and Nutrition (2020)
21. Effect of Curcumin on Proinflammatory Cytokines: A Meta-Analysis of Randomized Controlled Trials, Cytokine (2021)
22. Effect of Statins on the Plasma/Serum Levels of Inflammatory Markers in Patients With Cardiovascular Disease; a Systematic Review and Meta-Analysis of Randomized Clinical Trials, Inflammopharmacology (2022)
23. The Long-Term Effect of Exposure to Respirable Particulate Matter on the Incidence of Myocardial Infarction: A Systematic Review and Meta-Analysis Study, Environmental Science and Pollution Research (2022)
24. Zinc Status in Cystic Fibrosis Patients; a Systematic Review and Meta-Analysis, Heliyon (2024)
25. Are Alterations Needed in Silybum Marianum (Silymarin) Administration Practices? a Novel Outlook and Meta-Analysis on Randomized Trials Targeting Liver Injury, BMC Complementary Medicine and Therapies (2025)
26. Evaluation of Blood Levels of C-Reactive Protein Marker in Obstructive Sleep Apnea: A Systematic Review, Meta-Analysis and Meta-Regression, Life (2021)
27. Metabolic Syndrome and Its Components Are Associated With Increased Chronic Kidney Disease Risk: Evidence From a Meta-Analysis on 11 109 003 Participants From 66 Studies, International Journal of Clinical Practice (2018)
28. Is Leukocyte Telomere Length Related With Lung Cancer Risk?: A Meta-Analysis, Iranian Biomedical Journal (2017)
29. A Posteriori Dietary Patterns and Risk of Pancreatic and Renal Cancers: A Systematic Review and Meta-Analysis, Nutrition and Food Science (2017)
30. Association of Hla-Dra and Il2ra Polymorphisms With the Severity and Relapses Rate of Multiple Sclerosis in an Iranian Population, Reports of Biochemistry and Molecular Biology (2020)
31. Consumption of Whole Grains and Risk of Type 2 Diabetes: A Comprehensive Systematic Review and Dose–Response Meta-Analysis of Prospective Cohort Studies, Food Science and Nutrition (2022)
32. Prevalence of Diabetic Retinopathy in Iran: A Systematic Review and Meta-Analysis, International Journal of Ophthalmology (2017)
33. Effect of Statins on Serum Level of Hs-Crp and Crp in Patients With Cardiovascular Diseases: A Systematic Review and Meta-Analysis of Randomized Controlled Trials, Mediators of Inflammation (2022)
34. Dietary Carbohydrate and the Risk of Type 2 Diabetes: An Updated Systematic Review and Dose–Response Meta-Analysis of Prospective Cohort Studies, Scientific Reports (2022)
35. Effect of Curcumin on C-Reactive Protein As a Biomarker of Systemic Inflammation: An Updated Meta-Analysis of Randomized Controlled Trials, Phytotherapy Research (2022)
36. The Effect of Acarbose on Inflammatory Cytokines and Adipokines in Adults: A Systematic Review and Meta-Analysis of Randomized Clinical Trials, Inflammopharmacology (2024)
37. Effect of Resveratrol on C-Reactive Protein: An Updated Meta-Analysis of Randomized Controlled Trials, Phytotherapy Research (2021)
38. Thalamic Magnetic Susceptibility (Χ) Alterations in Neurodegenerative Diseases: A Systematic Review and Meta-Analysis of Quantitative Susceptibility Mapping Studies, Journal of Magnetic Resonance Imaging (2025)
39. Glymphatic Pathway Dysfunction in Severe Obstructive Sleep Apnea: A Meta-Analysis, Sleep Medicine (2025)
40. A Posteriori Dietary Patterns and Risk of Inflammatory Bowel Disease: A Meta-Analysis of Observational Studies, International Journal for Vitamin and Nutrition Research (2020)
41. The Effect of Personalized Intelligent Digital Systems for Self-Care Training on Type Ii Diabetes: A Systematic Review and Meta-Analysis of Clinical Trials, Acta Diabetologica (2023)
42. The Relation of Healthy and Western Dietary Patterns to the Risk of Endometrial and Ovarian Cancers: A Systematic Review and Meta-Analysis, International Journal for Vitamin and Nutrition Research (2020)
43. Evaluation of Serum and Plasma Interleukin-6 Levels in Obstructive Sleep Apnea Syndrome: A Meta-Analysis and Meta-Regression, Frontiers in Immunology (2020)
44. Vitamin D Receptor Gene Polymorphism and Susceptibility to Asthma: Meta-Analysis Based on 17 Case-Control Studies, Annals of Allergy# Asthma and Immunology (2020)
45. Impact of Melatonin Supplementation on Glycemic Parameters in Patients With Type 2 Diabetes: A Systematic Review and Meta-Analysis, Current Pharmaceutical Design (2025)
46. Comparison of Cartilage With Temporalis Fascia Tympanoplasty: A Meta-Analysis of Comparative Studies, Laryngoscope (2017)
47. Metabolic Phenotypes of Obese, Overweight, and Normal Weight Individuals and Risk of Chronic Kidney Disease: A Systematic Review and Meta-Analysis, Archives of Endocrinology and Metabolism (2019)
48. The Effects of Sildenafil on Fetal Doppler Indices: A Systematic Review and Meta-Analysis, Journal of Advances in Medical and Biomedical Research (2020)
49. Effect of Statins on the Blood Lipid Profile in Patients With Different Cardiovascular Diseases: A Systematic Review With Meta-Analysis of Randomized Clinical Trials, Current Medicinal Chemistry (2023)
50. Coffee Consumption and Cardiovascular Diseases and Mortality in Patients With Type 2 Diabetes: A Systematic Review and Dose–Response Meta-Analysis of Cohort Studies, Nutrition# Metabolism and Cardiovascular Diseases (2021)