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Statin Therapy and C-Reactive Protein in Patients With Kidney Disease: A Systematic Review and Meta-Analysis of Randomized Clinical Trials Publisher Pubmed



Razi B1 ; Imani D2 ; Aslani S3, 4 ; Reiner Z5 ; Sahebkar A6, 7, 8
Authors
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Authors Affiliations
  1. 1. Department of Laboratory Sciences and Hematology, Faculty of Paramedicine, North Khorasan University of Medical Sciences, Bojnurd, Iran
  2. 2. Department of Immunology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran
  3. 3. Centre for Innate Immunity and Infectious Diseases, Hudson Institute of Medical Research, Clayton, 3168, VIC, Australia
  4. 4. Department of Molecular and Translational Sciences, Faculty of Medicine, Nursing and Health Sciences, Monash University, Clayton, 3168, VIC, Australia
  5. 5. Department of Internal Medicine, University Hospital Center Zagreb, University of Zagreb, Zagreb, Croatia
  6. 6. Center for Global Health Research, Saveetha Medical College and Hospitals, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai, India
  7. 7. Biotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran
  8. 8. Applied Biomedical Research Center, Mashhad University of Medical Sciences, Mashhad, Iran

Source: Current Drug Targets Published:2025


Abstract

Background: Increased levels of inflammation markers in patients with kidney disease, particularly chronic kidney disease (CKD) is an important risk factor. This study explored whether the effect of more potent statins on inflammation in CKD patients is dose-dependent, whether there is any difference between the hydrophilic and lipophilic statins concerning their effects on inflammation markers in patients with CKD, and whether the duration of treatment with statins has any effect on markers of inflammation in these patients. Methods: A systematic literature search of Scopus, PubMed, and ISI Web of Science databases from inception to August 2022 was performed. Eligible studies were stratified based on a target population, intervention duration, dosage and type of statins (high intensity statin and moderate/low intensity), and solubility of statins. Publication bias was evaluated using Begg’s regression asymmetry test for visual inspection of funnel plots. Non-linear effects of dosage of statins and treatment duration were also examined by fractional polynomial modeling. Results: Meta-analysis of 10 RCTs (12 studies) on 264 patients with kidney disease and 254 controls showed a significant hs-CRP lowering effect of the dose of statin. Both hydrophilic and lipophilic statins had significant hs-CRP lowering effects. Meta-analysis of 6 publications (7 studies) evaluating the impact of statins on CRP in 235 patients and 197 control subjects showed a significant negative association between treatment with statins group and CRP levels. Conclusion: Statin treatment decreases significantly the levels of CRP and hs-CRP in patients with kidney disease. © 2025 Bentham Science Publishers.
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