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Effects of Statins on Renin–Angiotensin System Publisher



Kiaie N1 ; Gorabi AM1 ; Reiner Z2 ; Jamialahmadi T3, 4 ; Ruscica M5 ; Sahebkar A6, 7, 8, 9
Authors
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Authors Affiliations
  1. 1. Research Center for Advanced Technologies in Cardiovascular Medicine, Tehran Heart Center, Tehran University of Medical Sciences, Tehran, 1411713138, Iran
  2. 2. Department of Internal Diseases, School of Medicine, University Hospital Center Zagreb, Zagreb University, Zagreb, 10000, Croatia
  3. 3. Quchan Branch, Department of Food Science and Technology, Islamic Azad University, Quchan, 9479176135, Iran
  4. 4. Department of Nutrition, Mashhad University of Medical Sciences, Mashhad, 9177948564, Iran
  5. 5. Department of Pharmacological and Biomolecular Sciences, Universita degli Studi di Milano, Milan, 20133, Italy
  6. 6. Biotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, 9177948564, Iran
  7. 7. Applied Biomedical Research Center, Mashhad University of Medical Sciences, Mashhad, 9177948564, Iran
  8. 8. School of Medicine, The University of Western Australia, Perth, 6009, Australia
  9. 9. School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, 9177948564, Iran

Source: Journal of Cardiovascular Development and Disease Published:2021


Abstract

Statins, a class of drugs for lowering serum LDL-cholesterol, have attracted attention because of their wide range of pleiotropic effects. An important but often neglected effect of statins is their role in the renin–angiotensin system (RAS) pathway. This pathway plays an integral role in the progression of several diseases including hypertension, heart failure, and renal disease. In this paper, the role of statins in the blockade of different components of this pathway and the underlying mechanisms are reviewed and new therapeutic possibilities of statins are suggested. © 2021 by the authors. Licensee MDPI, Basel, Switzerland.
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