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Sex Hormone Binding Globulin for Prediction of Gestational Diabetes Mellitus in Pre-Conception and Pregnancy: A Systematic Review Publisher Pubmed



Faal S1 ; Abedi P2 ; Jahanfar S3 ; Ndeke JM4 ; Mohaghegh Z5 ; Sharifipour F6 ; Zahedian M7
Authors
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Authors Affiliations
  1. 1. Department of Midwifery, Marand Branch, Islamic Azad University, Marand, Iran
  2. 2. Menopause Andropause Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
  3. 3. School of Health Sciences-MPH Program Health Professions Building 2212, Central Michigan University, United States
  4. 4. School of Health Sciences - MPH Program, Central Michigan University (CMU), Mount Pleasant, 48859, MI, United States
  5. 5. Unit of Family Health, Health Deputy of Tehran University of Medical Science, Tehran, Iran
  6. 6. School of Nursing and Midwifery, Kermanshah University of Medical Sciences, Kermanshah, Iran
  7. 7. Librarian of Nursing and Midwifery School, Ahvaz Jundishapur University of Medical Science, Ahvaz, Iran

Source: Diabetes Research and Clinical Practice Published:2019


Abstract

Aim: The purpose of the present study was to assess the relationship of sex hormone binding globulin (SHBG) and gestational diabetes mellitus (GDM). Methods: The Cochrane Library, Medline, ScienceDirect, and Web of Science were searched for studies published from the inception of the databases up to February 2019. Our inclusion criteria were published observational full-text articles. All data were analyzed using Review Manager 5.3. Of 208 papers reviewed, 26 studies (n = 6668) were considered for meta-analysis. Results: The SHBG level was significantly lower in women with GDM compared to healthy women (MD = −11.86; 95% CI: [−13.02, −10.71]). Also, SHBG in women with PCOS and GDM and obesity was significantly lower than women with PCOS without GDM (MD = −38.14; 95% CI: [−56.79, −19.48]) and normal weight women (MD: −58.96; 95% CI: [−79.32, −38.59]). SHBG in the second trimester was lower than that in the first trimester and pre-conception. Conclusions: This systematic review showed that the level of SHBG is significantly lower in GDM pregnant women than that in healthy women. The results of this systematic review about the relationship of GDM and SHBG and suggestion to assess this marker in early pregnancy should be considered with caution. © 2019 Elsevier B.V.
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