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The Potential Role of Intestinal Stem Cells and Microbiota for the Treatment of Colorectal Cancer Publisher Pubmed



B Arjmand BABAK ; S Alavimoghadam SEPIDEH ; Z Faraji ZAHRA ; M Aghajanpoorpasha MORTEZA ; H Jalaeikhoo HASAN ; M Rajaeinejad MOHSEN ; M Nikandish MOHSEN ; A Faridfar ALI ; Ar Mafi Ahmad R ; M Rezaeitavirani MOSTAFA
Authors

Source: Advances in Experimental Medicine and Biology Published:2024


Abstract

Colorectal cancer is a global health concern with high incidence and mortality rates. Conventional treatments like surgery, chemotherapy, and radiation therapy have limitations in improving patient survival rates. Recent research highlights the role of gut microbiota and intestinal stem cells in maintaining intestinal health and their potential therapeutic applications in colorectal cancer treatment. The interaction between gut microbiota and stem cells influences epithelial self-renewal and overall intestinal homeostasis. Novel therapeutic approaches, including immunotherapy, targeted therapy, regenerative medicine using stem cells, and modulation of gut microbiota, are being explored to improve treatment outcomes. Accordingly, this chapter provides an overview of the potential therapeutic applications of gut microbiota and intestinal stem cells in treating colorectal cancer. © 2024 Elsevier B.V., All rights reserved.
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