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Activation of Complement: A Potent Biomarker in Multiple Sclerosis Publisher



Sadeghmousavi S1, 2 ; Rezaei N2, 3, 4
Authors
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Authors Affiliations
  1. 1. School of Medicine, Shahidbeheshti University of Medical Sciences (SBMU), Tehran, Iran
  2. 2. Network of Immunity in Infection, Malignancy and Autoimmunity (NIIMA), Universal Scientific Education and Research Network (USERN), Tehran, Iran
  3. 3. Research Center for Immunodeficiencies, Children's Medical Center, Tehran University of Medical Sciences, Tehran, Iran
  4. 4. Department of Immunology, School of Medicine, Tehran University of Medical Sciences (TUMS), Tehran, Iran

Source: Translational Neuroimmunology: Multiple Sclerosis: Volume 8 Published:2023


Abstract

Multiple sclerosis (MS) is an autoimmune inflammatory disorder of the central nervous system (CNS), which is caused by demyelination, axonal damage, and plaque formation within the CNS. The interaction of inflammatory mediators results in MS pathogenesis and, consequently, neurological deficits. One of the involved inflammatory components is complement. It has been suggested that induced progressive inflammation caused by complement leads to cell and myelin damage, microglial activation, and chemoattraction. The objective of this chapter is to review the literature concerning complement activation in MS, which can help in comprehending the role of complement in MS and thus in designing therapeutic approaches to target complement and control this autoimmune disorder. © 2023 Elsevier Inc. All rights reserved.
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