Understanding the Immunologic Characteristics of Neurologic Manifestations of Sars-Cov-2 and Potential Immunological Mechanisms

Understanding the Immunologic Characteristics of Neurologic Manifestations of Sars-Cov-2 and Potential Immunological Mechanisms Publisher Pubmed

Mohammadi S^{1, 2} ; Moosaie F^{1, 2} ; Aarabi MH¹

Source: Molecular Neurobiology Published:2020

Abstract

Similar to its predecessors, coronavirus disease 2019 (COVID-19) exhibits neurotrophic properties, which lead to progression of neurologic sequelae. Besides direct viral invasion to the central nervous system (CNS), indirect CNS involvement through viral-mediated immune response is plausible. Aberrant immune pathways such as extreme release of cytokines (cytokine storm), autoimmunity mediated by cross-reactivity between CNS components and viral particles, and microglial activation propagate CNS damage in these patients. Here, we review the currently available evidence to discuss the plausible immunologic pathways that may contribute to the development of COVID-19 neurological complications, namely Alzheimer’s disease, Parkinson’s disease, stroke, multiple sclerosis, Guillain-Barre syndrome, seizure, and brainstem involvement. © 2020, Springer Science+Business Media, LLC, part of Springer Nature.

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Style	Citing Format
MLA	Mohammadi S, Moosaie F, Aarabi MH. "Understanding the Immunologic Characteristics of Neurologic Manifestations of Sars-Cov-2 and Potential Immunological Mechanisms." Molecular Neurobiology, vol. 57, no. 12, 2020, pp. 5263-5275.
APA	Mohammadi S, Moosaie F, Aarabi MH (2020). Understanding the Immunologic Characteristics of Neurologic Manifestations of Sars-Cov-2 and Potential Immunological Mechanisms. Molecular Neurobiology, 57(12), 5263-5275.
Chicago	Mohammadi S, Moosaie F, Aarabi MH. "Understanding the Immunologic Characteristics of Neurologic Manifestations of Sars-Cov-2 and Potential Immunological Mechanisms." Molecular Neurobiology 57, no. 12 (2020): 5263-5275.
Harvard	Mohammadi S, Moosaie F, Aarabi MH (2020) 'Understanding the Immunologic Characteristics of Neurologic Manifestations of Sars-Cov-2 and Potential Immunological Mechanisms', Molecular Neurobiology, 57(12), pp. 5263-5275.
Vancouver	Mohammadi S, Moosaie F, Aarabi MH. Understanding the Immunologic Characteristics of Neurologic Manifestations of Sars-Cov-2 and Potential Immunological Mechanisms. Molecular Neurobiology. 2020;57(12):5263-5275.
BibTex	@article{ author = {Mohammadi S and Moosaie F and Aarabi MH}, title = {Understanding the Immunologic Characteristics of Neurologic Manifestations of Sars-Cov-2 and Potential Immunological Mechanisms}, journal = {Molecular Neurobiology}, volume = {57}, number = {12}, pages = {5263-5275}, year = {2020} }
RIS	TY - JOUR AU - Mohammadi S AU - Moosaie F AU - Aarabi MH TI - Understanding the Immunologic Characteristics of Neurologic Manifestations of Sars-Cov-2 and Potential Immunological Mechanisms JO - Molecular Neurobiology VL - 57 IS - 12 SP - 5263 EP - 5275 PY - 2020 ER -

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