Co-Administration of Soy Isoflavones and Vitamin D in Management of Irritable Bowel Disease

Co-Administration of Soy Isoflavones and Vitamin D in Management of Irritable Bowel Disease Publisher Pubmed

Jalili M¹ ; Hekmatdoost A² ; Vahedi H³ ; Poustchi H⁴ ; Khademi B⁵ ; Saadi M⁵ ; Zemestani M⁶ ; Janani L⁷

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1. Department of Biology, Norwegian University of Science and Technology (NTNU), Trondheim, Norway
2. National Nutrition and Food Technology Research Institute, Faculty of Nutrition and Food Technology, Shahid Beheshti University of Medical Sciences, Tehran, Iran
3. Digestive Disease Research Center (DDRC), Digestive Disease Research Institute, Tehran, Iran
4. Liver and Pancreatic Biliary Research Group, Digestive Disease Research Institute, Tehran, Iran
5. Stu' Research Committee, Faculty of Nutrition and Food Technology, Shahid Beheshti University of Medical Sciences, Tehran, Iran
6. Stu' Research Committee, Faculty of Nutrition, Tabriz University of Medical Sciences, Tabriz, Iran
7. Department of Biostatistics, School of Public Health, Iran University of Medical Sciences, Tehran, Iran

Source: PLoS ONE Published:2016

Abstract

Background and Aims The substantial characteristics of Irritable Bowel Syndrome (IBS) are associated with estrogens in women. Both soy isoflavones and vitamin D can modulate estrogen receptors in the colonic smooth muscles. The aim of this study was to investigate the effects of soy isoflavones, vitamin D and their probable interactions in women with IBS. Methods In a factorial blinded randomized clinical trial, 100 women with IBS (age:18-75yr, were randomly assigned in 4 arms to receive either placebo of vitamin D and placebo of soy isoflavones (P+P), or placebo of vitamin D and soy isoflavones (P+S), or vitamin D and placebo of soy isoflavones (D+P), or vitamin D and soy isoflavones (D+S) for 6 weeks. Dosage of soy isoflavone was 2 capsules of 20 mg soy isoflavones per day, and dosage of vitamin D was one pearl of 50'000 IU biweekly. The clinical outcomes were IBS symptoms severity scores (IBS-SSS), disease- specific quality of life (IBS-QOL) and total score (IBS-TS) that evaluated at weeks 0, 6, and 10, and compared to each other. Results IBS-TS improved significantly in both S+P and D+P groups (p- value = 0.004, 0.015). The interaction effect of soy isoflavones and vitamin D on IBS-TS was significant (p<0.05). The interaction effect of soy isoflavones with vitamin D and the main effect of vitamin D on IBS-SSS were not statistically significant, whereas IBS-SSS decreased significantly in S+P and D+P groups (p-value = 0.001, 0.047 respectively). Conclusion Our results indicate that co-administration of soy isoflavones with vitamin D did not improve the IBS- SSS and IBS- QOL; however, it improved the IBS-TS. Trial Registration Clinical Trials.gov NCT02026518. © 2016 Jalili et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

2. Natural Polyphenols for the Prevention of Irritable Bowel Syndrome: Molecular Mechanisms and Targets; a Comprehensive Review, DARU# Journal of Pharmaceutical Sciences (2019)

3. Soy Isoflavones and Cholecalciferol Reduce Inflammation, and Gut Permeability, Without Any Effect on Antioxidant Capacity in Irritable Bowel Syndrome: A Randomized Clinical Trial, Clinical Nutrition ESPEN (2019)

4. Effectiveness of Probiotics in Irritable Bowel Syndrome: Updated Systematic Review With Meta-Analysis, World Journal of Gastroenterology (2015)

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Hossein Poustchi (2)

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Style	Citing Format
MLA	Jalili M, et al.. "Co-Administration of Soy Isoflavones and Vitamin D in Management of Irritable Bowel Disease." PLoS ONE, vol. 11, no. 8, 2016, pp. -.
APA	Jalili M, Hekmatdoost A, Vahedi H, Poustchi H, Khademi B, Saadi M, Zemestani M, Janani L (2016). Co-Administration of Soy Isoflavones and Vitamin D in Management of Irritable Bowel Disease. PLoS ONE, 11(8), -.
Chicago	Jalili M, Hekmatdoost A, Vahedi H, Poustchi H, Khademi B, Saadi M, Zemestani M, Janani L. "Co-Administration of Soy Isoflavones and Vitamin D in Management of Irritable Bowel Disease." PLoS ONE 11, no. 8 (2016): -.
Harvard	Jalili M et al. (2016) 'Co-Administration of Soy Isoflavones and Vitamin D in Management of Irritable Bowel Disease', PLoS ONE, 11(8), pp. -.
Vancouver	Jalili M, Hekmatdoost A, Vahedi H, Poustchi H, Khademi B, Saadi M, et al.. Co-Administration of Soy Isoflavones and Vitamin D in Management of Irritable Bowel Disease. PLoS ONE. 2016;11(8):-.
BibTex	@article{ author = {Jalili M and Hekmatdoost A and Vahedi H and Poustchi H and Khademi B and Saadi M and Zemestani M and Janani L}, title = {Co-Administration of Soy Isoflavones and Vitamin D in Management of Irritable Bowel Disease}, journal = {PLoS ONE}, volume = {11}, number = {8}, pages = {-}, year = {2016} }
RIS	TY - JOUR AU - Jalili M AU - Hekmatdoost A AU - Vahedi H AU - Poustchi H AU - Khademi B AU - Saadi M AU - Zemestani M AU - Janani L TI - Co-Administration of Soy Isoflavones and Vitamin D in Management of Irritable Bowel Disease JO - PLoS ONE VL - 11 IS - 8 SP - EP - PY - 2016 ER -

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