Tehran University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
Are Supplementation of Omega-3 and Ascorbic Acid Effective in Reducing Oxidative Stress and Depression Among Depressed Shift Workers? Publisher



Khajehnasiri F1 ; Akhondzadeh S2 ; Mortazavi SB3, 6 ; Allameh A4 ; Sotoudeh G5 ; Khavanin A3, 6 ; Zamanian Z7
Authors
Show Affiliations
Authors Affiliations
  1. 1. Department of Community Medicine, School of medicine, Tehran University of Medical Sciences, Tehran, Iran
  2. 2. Psychiatric Research Center, Roozbeh Hospital, Tehran University of Medical Sciences, Tehran, Iran
  3. 3. Department of Occupational Health, School of Medical Sciences, Tarbiat Modares University, Tehran, Iran
  4. 4. Department of Biochemistry, School of Medical Sciences, Tarbiat Modares University, Tehran, Iran
  5. 5. Department of Community Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, Tehran, Iran
  6. 6. Department of Occupational Health, School of Medical Sciences, Tarbiat Modares University, Tehran, Iran
  7. 7. Department of occupational Health, School of Health, Shiraz University of Medical Sciences, Shiraz, Iran

Source: International Journal for Vitamin and Nutrition Research Published:2015


Abstract

Background: This study assessed the effect of supplementation of omega-3 fatty acids and ascorbic acid alone and in combination on the level of lipid peroxidation (malondialdehyde, MDA concentration), total antioxidant capacity (TAC) and depression scores in depressed rotational shift workers in the Tehran Shahid Tondgoyan Oil refi nery. Material and methods: In this randomized, double-blind, placebo-controlled trial, 136 men who met the inclusion and exclusion criteria and had a Beck Depression Inventory (BDI) score ≥ 10 were selected. Among the participants, 33 received omega-3 fatty acid soft gel (1000 mg twice daily) with vitamin C (250 mg twice daily) (group 1), 31 took omega-3 fatty acid supplements and vitamin C placebo (group 2), 30 took omega-3 fatty acid supplement placebo and vitamin C (group 3), and 32 received omega-3 fatty acid supplement placebo and vitamin C placebo (group 4) for 2 months. Measured were serum MDA, TAC concentrations, and BDI scores at baseline and after 2 months. Results: This study showed that the BDI score was reduced signifi cantly in all 4 groups, however, the level of decrease was more in the omega-3 fatty acid (alone) supplementation group (mean 6.29 score decrease) (p < 0.001). MDA level decreased signifi cantly in groups with omega-3 fatty acids (mean 0.78 μmol/L ± 1.64 μmol/L decrease) (p = 0.014) or vitamin C supplementation alone (mean 0.74 μmol/L ± 1.55 μmol/L decrease) (p = 0.014), but not in combination. Conclusions: Supplementation of omega-3 fatty acids alone and not in combination with vitamin C had a better impact on depression and MDA level pronounced in depressed male shift workers. © 2016 Hans Huber Publishers, Hogrefe AG, Bern.
Related Docs
1. Effect of Omega-3 Fatty Acids on Depressive Symptoms in Hiv-Positive Individuals: A Randomized, Placebo-Controlled Clinical Trial, Annals of Pharmacotherapy (2016)
2. Effects of Omega-3 Fatty Acids Supplement on Antioxidant Enzymes Activity in Type 2 Diabetic Patients, Iranian Journal of Public Health (2016)
3. Antioxidant Status and Endocannabinoid Concentration in Postpartum Depressive Women, Tehran University Medical Journal (2015)
4. Beneficial Effects of Omega-3 and Vitamin E Coadministration on Gene Expression of Sirt1 and Pgc1α and Serum Antioxidant Enzymes in Patients With Coronary Artery Disease, Nutrition# Metabolism and Cardiovascular Diseases (2016)
Experts (# of related papers)
View all Related Experts
Hossein Khalili (1)
Mohammad Arbabi (1)