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The Effect of Hiv/Aids Infection on the Clinical Outcomes of Covid-19: A Meta-Analysis Publisher Pubmed



Moradi Y1 ; Soheili M3 ; Dehghanbanadak H4 ; Moradi G1 ; Moradpour F1 ; Mortazavi SMM5 ; Kohan HG6 ; Zareie M2
Authors
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Authors Affiliations
  1. 1. Social Determinants of Health Research Center, Research Institute for Health Development, Department of Epidemiology and Biostatistics, School of Medicine, Kurdistan University of Medical Sciences, Sanandaj, Iran
  2. 2. Department of Epidemiology and Biostatistics, School of Medicine, Kurdistan University of Medical Sciences, Sanandaj, Iran
  3. 3. Faculty of Medicine, Kermanshah University of Medical Sciences, Kermanshah, Iran
  4. 4. Students Scientific Research Center, Tehran University of Medical Sciences, Tehran, Iran
  5. 5. Pediatric Gastroenterology Fellowship, Department of Pediatrics, School of Medicine, Namazi teaching Hospital, Shiraz University of Medical Sciences, Shiraz, Iran
  6. 6. Department of Pharmaceutical and Administrative Sciences, College of Pharmacy, Western New England University, MA, United States

Source: Journal of Pharmacy and Pharmaceutical Sciences Published:2022


Abstract

Purpose: Patients with HIV may be more likely to become severely ill from COVID-19. The present meta-analysis aims to determine the impact of HIV/AIDS infection on the clinical outcomes of COVID-19. Methods: A comprehensive literature search was performed to identify relevant cohort studies to evaluate the association of HIV/AIDS infection with clinical outcomes of COVID-19. International databases, including PubMed (Medline), Web of Sciences, Scopus, and Embase, were searched from the emergence of the COVID-19 pandemic until January 2022. We utilized the risk ratio (RR) with its 95% confidence interval (95% CI) to quantify the effect of cohort studies. Results: Twelve cohort studies were included in this meta-analysis, which examined a total number of 17,786,384 patients. Among them, 40,386 were identified to be HIV positive, and 17,745,998 were HIV negative. The pooled analyses showed HIV positive patients who were co-infected with SARS-CoV-2 were 58% more likely to develop a fever (RR=1.58; 95% CI: 1.42, 1.75), 24% more likely to have dyspnea (RR=1.24; 95% CI: 1.08, 1.41), 45% more likely to be admitted to ICU (RR=1.45; 95% CI: 1.26, 1.67), and 37% more likely to die from to COVID-19 (RR=1.37; 95% CI: 1.30, 1.45) than HIV negative patients. Conclusion: HIV/AIDS coinfection with COVID 19 increased the risk of fever, dyspnea, ICU admission, and mortality. © 2022, Canadian Society for Pharmaceutical Sciences. All rights reserved.
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