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Covid-19: A Systematic Review and Update on Prevention, Diagnosis, and Treatment Publisher



Aghamirza Moghim Aliabadi H1, 2 ; Eivazzadehkeihan R3 ; Beig Parikhani A4 ; Fattahi Mehraban S5 ; Maleki A3 ; Fereshteh S6 ; Bazaz M4 ; Zolriasatein A5 ; Bozorgnia B7 ; Rahmati S4 ; Saberi F8 ; Yousefi Najafabadi Z9, 10 ; Damough S4 ; Mohseni S5 Show All Authors
Authors
  1. Aghamirza Moghim Aliabadi H1, 2
  2. Eivazzadehkeihan R3
  3. Beig Parikhani A4
  4. Fattahi Mehraban S5
  5. Maleki A3
  6. Fereshteh S6
  7. Bazaz M4
  8. Zolriasatein A5
  9. Bozorgnia B7
  10. Rahmati S4
  11. Saberi F8
  12. Yousefi Najafabadi Z9, 10
  13. Damough S4
  14. Mohseni S5
  15. Salehzadeh H11
  16. Khakyzadeh V12
  17. Madanchi H13, 14
  18. Kardar GA9, 10
  19. Zarrintaj P15
  20. Saeb MR16
  21. Mozafari M17
Show Affiliations
Authors Affiliations
  1. 1. Protein Chemistry Laboratory, Department of Medical Biotechnology, Biotechnology Research Center, Pasteur Institute of Iran, Tehran, Iran
  2. 2. Advance Chemical Studies Laboratory, Faculty of Chemistry, K. N. Toosi University, Tehran, Iran
  3. 3. Department of Chemistry, Iran University of Science and Technology, Tehran, Iran
  4. 4. Department of Medical Biotechnology, Biotechnology Research Center, Pasteur Institute, Tehran, Iran
  5. 5. Non-metallic Materials Research Group, Niroo Research Institute, Tehran, Iran
  6. 6. Department of Bacteriology, Pasteur Institute of Iran, Tehran, Iran
  7. 7. Faculty of Chemistry, Alzahra University, Tehran, Iran
  8. 8. Department of Medical Biotechnology, School of Advanced Technologies in Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  9. 9. Department of Medical Biotechnology, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran, Iran
  10. 10. Immunology, Asthma & Allergy Research Institute, Tehran University of Medical Sciences, Tehran, Iran
  11. 11. Faculty of Chemistry, Kharazmi University, Tehran, Iran
  12. 12. Department of Chemistry, K. N. Toosi University of Technology, Tehran, Iran
  13. 13. School of Medicine, Semnan University of Medical Sciences, Semnan, Iran
  14. 14. Drug Design and Bioinformatics Unit, Department of Medical Biotechnology, Biotechnology Research Center, Pasteur Institute of Iran, Tehran, Iran
  15. 15. School of Chemical Engineering, Oklahoma State University, Stillwater, OK, United States
  16. 16. Department of Polymer Technology, Faculty of Chemistry, Gdansk University of Technology, Gdansk, Poland
  17. 17. Department of Tissue Engineering & Regenerative Medicine, Iran University of Medical Sciences, Tehran, Iran

Source: MedComm Published:2022


Abstract

Since the rapid onset of the COVID-19 or SARS-CoV-2 pandemic in the world in 2019, extensive studies have been conducted to unveil the behavior and emission pattern of the virus in order to determine the best ways to diagnosis of virus and thereof formulate effective drugs or vaccines to combat the disease. The emergence of novel diagnostic and therapeutic techniques considering the multiplicity of reports from one side and contradictions in assessments from the other side necessitates instantaneous updates on the progress of clinical investigations. There is also growing public anxiety from time to time mutation of COVID-19, as reflected in considerable mortality and transmission, respectively, from delta and Omicron variants. We comprehensively review and summarize different aspects of prevention, diagnosis, and treatment of COVID-19. First, biological characteristics of COVID-19 were explained from diagnosis standpoint. Thereafter, the preclinical animal models of COVID-19 were discussed to frame the symptoms and clinical effects of COVID-19 from patient to patient with treatment strategies and in-silico/computational biology. Finally, the opportunities and challenges of nanoscience/nanotechnology in identification, diagnosis, and treatment of COVID-19 were discussed. This review covers almost all SARS-CoV-2-related topics extensively to deepen the understanding of the latest achievements (last updated on January 11, 2022). © 2022 The Authors. MedComm published by Sichuan International Medical Exchange & Promotion Association (SCIMEA) and John Wiley & Sons Australia, Ltd.
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