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The Role of Inflammatory Mediators in the Pathogenesis of Alzheimer’S Disease Publisher



Azizi G1, 2 ; Navabi SS3 ; Alshukaili A4 ; Seyedzadeh MH3 ; Yazdani R2, 5 ; Mirshafiey A3
Authors
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Authors Affiliations
  1. 1. Department of Laboratory Medicine, Imam Hassan Mojtaba Hospital, Alborz University of Medical Sciences, Karaj, Iran
  2. 2. Research Center forImmunodeficiencies, Children’s Medical Center, Tehran University of Medical Sciences, Tehran, Iran
  3. 3. Department of Immunology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran
  4. 4. Health and Social Services Sector, The Research Council Oman, Muscat, Oman
  5. 5. Department of Immunology, Isfahan Universityof Medical Sciences, Isfahan, Iran

Source: Sultan Qaboos University Medical Journal Published:2015


Abstract

Alzheimer’s disease (AD), a neurodegenerative disorder associated with advanced age, is the most common cause of dementia globally. AD is characterised by cognitive dysfunction, deposition of amyloid plaques, neurofibrillary tangles and neuro-inflammation. Inflammation of the brain is a key pathological hallmark of AD. Thus, clinical and immunopathological evidence of AD could be potentially supported by inflammatory mediators, including cytokines, chemokines, the complement system, acute phase proteins and oxidative mediators. In particular, oxidative mediators may actively contribute to the progression of AD and on-going inflammation in the brain. This review provides an overview of the functions and activities of inflammatory mediators in AD. An improved understanding of inflammatory processes and their role in AD is needed to improve therapeutic research aims in the field of AD and similar diseases. © 2015, Sultan Qaboos University. All rights reserved.
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