Binder Design for Targeting Sars-Cov-2 Spike Protein: An in Silico Perspective

Binder Design for Targeting Sars-Cov-2 Spike Protein: An in Silico Perspective Publisher

Etemadi A¹ ; Moradi HR¹ ; Mohammadian F² ; Karimijafari MH³ ; Negahdari B¹ ; Asgari Y¹ ; Mazloomi M¹

Source: Gene Reports Published:2022

Abstract

Introduction: The COVID-19 pandemic is now affecting all people around the world and getting worse. New antiviral medications are desperately needed other than the few approved medications that have shown no promising efficacy so far. Methods: Here we report three blocking binders for targeting SARS-CoV-2 spike protein to block the interaction between the spike protein on the SARS-CoV-2 and the angiotensin-converting enzyme 2 (ACE2) receptors, responsible for viral homing into the alveolar epithelium type II cells (AECII). Results: The design process is based on the collected natural scaffolds and using Rosetta interface for designing the binders. Conclusion: Based on the structural analysis, three binders were selected, and the results showed that they might be promising as new therapeutic targets for blocking COVID-19. © 2021

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Style	Citing Format
MLA	Etemadi A, et al.. "Binder Design for Targeting Sars-Cov-2 Spike Protein: An in Silico Perspective." Gene Reports, vol. 26, no. , 2022, pp. -.
APA	Etemadi A, Moradi HR, Mohammadian F, Karimijafari MH, Negahdari B, Asgari Y, Mazloomi M (2022). Binder Design for Targeting Sars-Cov-2 Spike Protein: An in Silico Perspective. Gene Reports, 26(), -.
Chicago	Etemadi A, Moradi HR, Mohammadian F, Karimijafari MH, Negahdari B, Asgari Y, Mazloomi M. "Binder Design for Targeting Sars-Cov-2 Spike Protein: An in Silico Perspective." Gene Reports 26, no. (2022): -.
Harvard	Etemadi A et al. (2022) 'Binder Design for Targeting Sars-Cov-2 Spike Protein: An in Silico Perspective', Gene Reports, 26(), pp. -.
Vancouver	Etemadi A, Moradi HR, Mohammadian F, Karimijafari MH, Negahdari B, Asgari Y, et al.. Binder Design for Targeting Sars-Cov-2 Spike Protein: An in Silico Perspective. Gene Reports. 2022;26():-.
BibTex	@article{ author = {Etemadi A and Moradi HR and Mohammadian F and Karimijafari MH and Negahdari B and Asgari Y and Mazloomi M}, title = {Binder Design for Targeting Sars-Cov-2 Spike Protein: An in Silico Perspective}, journal = {Gene Reports}, volume = {26}, number = {}, pages = {-}, year = {2022} }
RIS	TY - JOUR AU - Etemadi A AU - Moradi HR AU - Mohammadian F AU - Karimijafari MH AU - Negahdari B AU - Asgari Y AU - Mazloomi M TI - Binder Design for Targeting Sars-Cov-2 Spike Protein: An in Silico Perspective JO - Gene Reports VL - 26 IS - SP - EP - PY - 2022 ER -

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