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Binder Design for Targeting Sars-Cov-2 Spike Protein: An in Silico Perspective Publisher



Etemadi A1 ; Moradi HR1 ; Mohammadian F2 ; Karimijafari MH3 ; Negahdari B1 ; Asgari Y1 ; Mazloomi M1
Authors
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Authors Affiliations
  1. 1. Medical Biotechnology Department, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences (TUMS), Tehran, Iran
  2. 2. Department of Medical Biotechnology, Faculty of Advanced Medical Sciences, Tabriz University of Medical Sciences, Tabriz, Iran
  3. 3. Department of Bioinformatics, Institute of Biochemistry and Biophysics, University of Tehran, Tehran, Iran

Source: Gene Reports Published:2022


Abstract

Introduction: The COVID-19 pandemic is now affecting all people around the world and getting worse. New antiviral medications are desperately needed other than the few approved medications that have shown no promising efficacy so far. Methods: Here we report three blocking binders for targeting SARS-CoV-2 spike protein to block the interaction between the spike protein on the SARS-CoV-2 and the angiotensin-converting enzyme 2 (ACE2) receptors, responsible for viral homing into the alveolar epithelium type II cells (AECII). Results: The design process is based on the collected natural scaffolds and using Rosetta interface for designing the binders. Conclusion: Based on the structural analysis, three binders were selected, and the results showed that they might be promising as new therapeutic targets for blocking COVID-19. © 2021
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