The Effect of Berberine Supplementation on Glycemic Control and Inflammatory Biomarkers in Metabolic Disorders: An Umbrella Meta-Analysis of Randomized Controlled Trials Publisher Pubmed



Nazari A¹ ; Ghotbabadi ZR² ; Kazemi KS³ ; Metghalchi Y⁴ ; Tavakoli R⁵ ; Rahimabadi RZ⁶ ; Ghaheri M⁷ Show Affiliations
Source: Clinical Therapeutics Published:2024

Abstract

Purpose: Several meta-analyses reported berberine (BBR) supplementation improves glycemic parameters and inflammatory marker, but findings remain inconsistent. Therefore, this study was conducted. Methods: We systematically searched PubMed, Embase, Web of Science, Scopus, and Google Scholar to identify the relevant meta-analyses up to April 2023. Findings: BBR supplementation was effective in reducing fasting blood glucose (FBG) (ESWMD: −0.77; 95% CI: −0.90 to −0.63, and ESSMD: −0.65; 95% CI: −0.83 to −0.47), hemoglobin A1C (HbA1C) (ESWMD: −0.57; 95% CI: −0.68 to −0.46), homeostasis model assessment for insulin resistance (HOMA-IR) (ESWMD: −1.04; 95% CI: −1.66 to −0.42, and ESSMD: −0.71; 95% CI: −0.97 to −0.46), insulin (ESWMD: −1.00; 95% CI: −1.70 to −0.30, and ESSMD: −0.63; 95% CI: −0.94 to −0.32), interleukin (IL)-6 (ESSMD: −1.23; 95% CI: −1.61 to −0.85), tumor necrosis factor-α (TNF-α) (ESSMD: −1.04; 95% CI: −1.28 to −0.79), and C-reactive protein (CRP) (ESWMD: −0.62; 95% CI: −0.74 to −0.50, and ESSMD: −1.70; 95% CI: −2.21 to −1.19). Implications: The finding of our umbrella showed that the supplementation of BBR could be effective in improving glycemic parameters and inflammatory marker in adults. © 2023 Elsevier Inc.