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A Systematic Review, Meta-Analysis, Dose-Response, and Meta-Regression of the Effects of Acarbose Intake on Glycemic Markers in Adults Publisher



Dehkordi SR1 ; Pahlavani N2 ; Nikbafshandiz M3 ; Bagheri R4 ; Rasaei N5 ; Darzi M6 ; Rastgoo S7, 8 ; Bahari H9 ; Shiraseb F5 ; Asbaghi O8, 10
Authors
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Authors Affiliations
  1. 1. Student Research Committee, Alborz University of Medical Sciences, Karaj, Iran
  2. 2. Health Sciences Research Center, Torbat Heydariyeh University of Medical Sciences, Torbat Heydariyeh, Iran
  3. 3. Student Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran
  4. 4. Department of Exercise Physiology, University of Isfahan, Isfahan, Iran
  5. 5. Department of Community Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences (TUMS), Tehran, Iran
  6. 6. Department of Nutrition Sciences and Research Branch, Islamic Azad University, Tehran, Iran
  7. 7. Department of Cellular and Molecular Nutrition, National Nutrition and Food Technology Research Institute, Faculty of Nutrition Science and Food Technology, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  8. 8. Student Research Committee, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  9. 9. Student Research Committee, Mashhad University of Medical Sciences, Mashhad, Iran
  10. 10. Cancer Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran

Source: Journal of Diabetes and Metabolic Disorders Published:2023


Abstract

Purpose: Prior research has yielded mixed results regarding the impact of acarbose intake on glycemic markers. To provide a more comprehensive analysis, a systematic review and meta-analysis was performed to compile data from various randomized controlled trials (RCTs) examining the effects of acarbose intake on fasting blood sugar (FBS), insulin, hemoglobin A1C (HbA1c), and homeostasis model assessment of insulin resistance (HOMA-IR) in adults. Methods: To identify relevant literature up to April 2023, a comprehensive search was conducted on various scholarly databases, including PubMed, Web of Science, and Scopus databases. The effect size of the studies was evaluated using a random-effects model to calculate the weighted mean differences (WMD) and 95% confidence intervals (CI). Heterogeneity between studies was assessed using Cochran’s Q test and I2. Results: This systematic review and meta-analysis included a total of 101 RCTs with a total of 107 effect sizes. The effect sizes for FBS in milligrams per deciliter (mg/dl), insulin in picomoles per liter (pmol/l), hemoglobin A1C (HbA1c) in percentage (%), and homeostasis model assessment of insulin resistance (HOMA-IR) were 92, 46, 80, and 22, respectively. The pooled analysis indicated that acarbose intake resulted in significant decreases in FBS (p = 0.018), insulin (p < 0.001), HbA1c (p < 0.001), and HOMA-IR (p < 0.001). Conclusion: The findings of this systematic review and meta-analysis suggest that acarbose intake can potentially lead to significant improvements in glycemic parameters by decreasing the levels of FBS, HbA1c, and insulin. However, larger and more rigorously designed studies are still needed to further evaluate and strengthen this association. © 2023, The Author(s), under exclusive licence to Tehran University of Medical Sciences.
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