Effects of Berberine and Barberry on Anthropometric Measures: A Systematic Review and Meta-Analysis of Randomized Controlled Trials Publisher Pubmed



Amini MR^{1, 2} ; Sheikhhossein F³ ; Naghshi S³ ; Djafari F¹ ; Askari M¹ ; Shahinfar H¹ ; Safabakhsh M¹ ; Jafari A¹ ; Shabbidar S¹ Show Affiliations
Source: Complementary Therapies in Medicine Published:2020

Abstract

Objective: Despite controversies, no study has systematically summarized findings from earlier studies on the effect of berberine and barberry on anthropometric measures. Therefore, the current systematic review and meta-analysis was conducted on the effect of berberine and barberry on body mass index (BMI), body weight (BW), waist circumference (WC) and waist-hip ratio (WHR) in adults. Methods: Relevant studies, published up to August 2019, were searched through PubMed/Medline, Scopus, ISI Web of Science, Embase and Google Scholar. All randomized clinical trials investigating the effect of berberine and barberry on the anthropometric measures including BMI, BW, WC or/and WHR were included. Results: Out of 252 citations, 12 trials that enrolled 849 subjects were included. Berberine and barberry resulted in no significant change in BMI (Weighted mean differences (WMD): -0.16 kg/m2; 95 % CI: -0.43 to 0.11, P = 0.247), BW (WMD: −0.11 kg; 95 % CI: −0.13 to 0.91, P = 0.830), and berberine resulted in not significant in WC (WMD: −0.58 cm; 95 % CI: −1.89 to 0.72, P = 0.379) and significant reduction in WHR (WMD: -0.03; 95 % CI: −0.04 to -0.01, P < 0.0001). Conclusion: We found a significant reduction in WHR following berberine consumption in adults. Further clinical trials with high quality according to challenges mentioned seem to be helpful to use berberine and barberry as a supplement for certain health conditions, efficiently. © 2020 Elsevier Ltd