Mutations in Hnf1a Gene Are Not a Common Cause of Familial Young-Onset Diabetes in Iran

Mutations in Hnf1a Gene Are Not a Common Cause of Familial Young-Onset Diabetes in Iran Publisher

Moghbeli M¹ ; Naghibzadeh B² ; Ghahraman M^{2, 3} ; Fatemi S⁴ ; Taghavi M⁵ ; Vakili R⁶ ; Abbaszadegan MR^{2, 3}

Show Affiliations

1. North Khorasan University of Medical Sciences, Bojnurd, Iran
2. Medical Genetics Research Center, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
3. Division of Human Genetics, Immunology Research Center, Avicenna Research Institute, Mashhad University of Medical Sciences, Mashhad, Iran
4. Immunogenetics Department, Immunology Research Center, Bu-Ali Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
5. Endocrinology and Metabolism Research Center, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
6. Department of Pediatric Endocrinology, School of Medicine, Imam Reza Hospital, Mashhad University of Medical Sciences, Mashhad, Iran

Source: Indian Journal of Clinical Biochemistry Published:2018

Abstract

Mutations in hepatocyte nuclear factor-1 alpha (HNF1A) as a homeodomain transcription factor which regulates variety of genes, are the most common cause of maturity-onset diabetes of the young (MODY). Detection of HNF1A mutations not only classifies the subtype, but also predicts the likely clinical course and may alters the method of treatment from insulin to the oral sulphonylureas, which is shown to improve glycemic control. The coding and promoter regions of HNF1A gene were screened for mutations in 34 unrelated Iranian MODY patients. We identified one novel missense mutation (C49G) and two novel polymorphisms and 8 recently identified SNPs in the HNF1A gene. It is possible that in Iran, other yet to be identified genes are responsible for the familial young onset diabetes. Hence, there is a need for more extensive genetic analyses in Iranian patients with familial young onset diabetes. © 2017, Association of Clinical Biochemists of India.

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Style	Citing Format
MLA	Moghbeli M, et al.. "Mutations in Hnf1a Gene Are Not a Common Cause of Familial Young-Onset Diabetes in Iran." Indian Journal of Clinical Biochemistry, vol. 33, no. 1, 2018, pp. 91-95.
APA	Moghbeli M, Naghibzadeh B, Ghahraman M, Fatemi S, Taghavi M, Vakili R, Abbaszadegan MR (2018). Mutations in Hnf1a Gene Are Not a Common Cause of Familial Young-Onset Diabetes in Iran. Indian Journal of Clinical Biochemistry, 33(1), 91-95.
Chicago	Moghbeli M, Naghibzadeh B, Ghahraman M, Fatemi S, Taghavi M, Vakili R, Abbaszadegan MR. "Mutations in Hnf1a Gene Are Not a Common Cause of Familial Young-Onset Diabetes in Iran." Indian Journal of Clinical Biochemistry 33, no. 1 (2018): 91-95.
Harvard	Moghbeli M et al. (2018) 'Mutations in Hnf1a Gene Are Not a Common Cause of Familial Young-Onset Diabetes in Iran', Indian Journal of Clinical Biochemistry, 33(1), pp. 91-95.
Vancouver	Moghbeli M, Naghibzadeh B, Ghahraman M, Fatemi S, Taghavi M, Vakili R, et al.. Mutations in Hnf1a Gene Are Not a Common Cause of Familial Young-Onset Diabetes in Iran. Indian Journal of Clinical Biochemistry. 2018;33(1):91-95.
BibTex	@article{ author = {Moghbeli M and Naghibzadeh B and Ghahraman M and Fatemi S and Taghavi M and Vakili R and Abbaszadegan MR}, title = {Mutations in Hnf1a Gene Are Not a Common Cause of Familial Young-Onset Diabetes in Iran}, journal = {Indian Journal of Clinical Biochemistry}, volume = {33}, number = {1}, pages = {91-95}, year = {2018} }
RIS	TY - JOUR AU - Moghbeli M AU - Naghibzadeh B AU - Ghahraman M AU - Fatemi S AU - Taghavi M AU - Vakili R AU - Abbaszadegan MR TI - Mutations in Hnf1a Gene Are Not a Common Cause of Familial Young-Onset Diabetes in Iran JO - Indian Journal of Clinical Biochemistry VL - 33 IS - 1 SP - 91 EP - 95 PY - 2018 ER -

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