Safety and Efficacy of 1550-Nm Non-Ablative Fractional Laser for Neck Rejuvenation Publisher Pubmed



Babaie H ; Khorasani Zadeh F ; Ansari M ; Aryanian Z ; Rahimnia A ; Ehsani AH ; Ehsani A ; Noormohammadpour P ; Shakoei S ; Razavi Z
Source: Lasers in Medical Science Published:2025

Abstract

This study was designed to determine the efficacy and safety of a 1550nm non-ablative fractional (NAFL) diode laser for neck skin rejuvenation. Both internal and external factors can cause the neck to age, leading to the development of wrinkles, laxity, and volume loss. Neck is more challenging to treat with conventional ablative methods due to its decreased vascularity and fewer adnexal structures. Although there is little information on the effectiveness of the 1550 nm NAFL for neck rejuvenation, it provides a minimally invasive option for reducing wrinkles and improving skin texture. Nineteen female patients aged 35-55; having moderate to severe neck wrinkles (WSRS scores 2–4), and Fitzpatrick skin types I–IV were enrolled. Patients underwent three monthly session of 1550-nm NAFL (Frax Pro™). Standardized photos were evaluated by dermatologists blinded to the study, using the Wrinkle Severity Rating Scale (WSRS). Changes in dermal and hypodermal thickness and elasticity were measured using shear wave elastography and high-frequency ultrasound. Three months after the last treatment session, patient satisfaction was measured. The treatment resulted in a significant clinical improvement in neck wrinkles. A significant shift in WSRS scores from severe/very severe to moderate levels (p < 0.001) happened. Dermal thickness increased significantly from 1.15 ± 0.20 mm to 1.30 ± 0.23 mm (p < 0.001), while hypodermal thickness decreased from 7.69 ± 2.06 mm to 6.57 ± 1.71 mm (p = 0.003). Dermal and hypodermal elasticity did not significantly change. The average patient satisfaction score was 6.68 ± 1.49 out of 10. Other than temporary erythema and edema, there were no significant side effects. The 1550-nm NAFL offers a minimally invasive, safe, and effective neck skin rejuvenation option with a short recovery period. It is capable of enhancing dermal thickness and wrinkle severity. © 2025 Elsevier B.V., All rights reserved.