Tehran University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
Pathogenesis of Breast Cancer Metastasis to Brain: A Comprehensive Approach to the Signaling Network Publisher Pubmed



Tayyeb B1 ; Parvin M1
Authors
Show Affiliations
Authors Affiliations
  1. 1. Department of Medical Genetics, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran

Source: Molecular Neurobiology Published:2016


Abstract

There is a general consensus that breast cancer is a rising trend disease in the world. It is one of the most common cancer types and is the leading cause of death among women’s cancers. There are several reasons for this high rate of mortality including metastasis which is responsible for about 90 % of cancer-related mortality. Therefore, recognition and understanding of metastatic process is important, and by considering the key role of pathophysiological route in metastasis as a multistep cascade of “invasion–metastasis,” it might modify and improve our insight toward this complex phenomenon. Moreover, it can provide novel approaches for designing advanced targeted therapies. The present work aimed to review the published papers regarding molecular basis of metastatic process of breast cancer to brain metastasis, especially related genes and signaling network. Furthermore, the use of molecular aspects of metastatic breast cancer to brain was discussed in horizon of future treatment of breast cancer. © 2014, Springer Science+Business Media New York.
Related Docs
View other Related Docs
1. Metastatic Breast Cancer at a Glance: Scenarios of Bc Brain- and Bc Bone-Metastasis by Illustrations, Cancer Genetics and Psychotherapy (2017)
2. Lung Cancer-Associated Brain Metastasis: Molecular Mechanisms and Therapeutic Options, Cellular Oncology (2017)
3. The Molecular Signature of Breast Cancer Metastasis to Bone, Anti-Cancer Drugs (2016)
4. Oxidative Stress: Development and Progression of Breast Cancer: Review Article, Tehran University Medical Journal (2017)
5. Antimetastatic Effects of Curcumin in Oral and Gastrointestinal Cancers, Frontiers in Pharmacology (2021)
6. Isolation and Characterization of the Primary Epithelial Breast Cancer Cells and the Adjacent Normal Epithelial Cells From Iranian Women’S Breast Cancer Tumors, Cytotechnology (2018)
7. Expression Patterns of Cxcl12 and Its Receptor in Colorectal Carcinoma, Clinical Laboratory (2018)
8. Tumor-Associated Macrophages and Epithelial–Mesenchymal Transition in Cancer: Nanotechnology Comes Into View, Journal of Cellular Physiology (2018)
Experts (# of related papers)
View all Related Experts
Nima Rezaei (2)
Alireza Biglari (2)
Other Related Docs
9. Comparison of Snail1, Zeb1, E-Cadherin Expression Levels in Hpv-Induced Cervical Cancer, Iranian Journal of Public Health (2020)
10. Evaluation of Exosomal Mir-9 and Mir-155 Targeting Pten and Dusp14 in Highly Metastatic Breast Cancer and Their Effect on Low Metastatic Cells, Journal of Cellular Biochemistry (2019)
11. Personalized Medicine in Breast Cancer: Pharmacogenomics Approaches, Pharmacogenomics and Personalized Medicine (2019)
12. Assessing the Prognostic Factors, Survival, and Recurrence Incidence of Triple Negative Breast Cancer Patients, a Single Center Study in Iran, PLoS ONE (2019)
13. The Pro-Tumorigenic Responses in Metastatic Niches: An Immunological Perspective, Clinical and Translational Oncology (2023)
14. Slug and Sox9 Cooperatively Regulate Tumor Initiating Niche Factors in Breast Cancer, Cancer Microenvironment (2016)
15. Exosomal Mirnas From Highly Metastatic Cells Can Induce Metastasis in Non-Metastatic Cells, Life Sciences (2019)
16. Can Color and Spectral Doppler Ultrasound of Breast Cancers Help to Predict the Immunohistochemistry Profile?, Archives of Breast Cancer (2019)
17. The Expression Analysis of Mest1 and Gja1 Genes in Gastric Cancer in Association With Clinicopathological Characteristics, International Journal of Hematology-Oncology and Stem Cell Research (2024)
18. Cancer Immunology, Encyclopedia of Infection and Immunity (2022)
19. Bone Metastasis Prognostic Factors in Breast Cancer, Breast Cancer: Basic and Clinical Research (2019)
20. Epigenetic of Retinoic Acid Receptor ß2 Gene in Breast Cancer, Epigenetics Territory and Cancer (2015)
21. Microrna As a Systemic Intervention in the Specific Breast Cancer Subtypes With C-Myc Impacts; Introducing Subtype-Based Appraisal Tool, Journal of Cellular Physiology (2018)
22. Enrichment of Cancer Stem-Like Cells by the Induction of Epithelial-Mesenchymal Transition Using Lentiviral Vector Carrying E-Cadherin Shrna in Ht29 Cell Line, Journal of Cellular Physiology (2019)
23. The Role of Probiotics in Cancer Treatment: Emphasis on Their in Vivo and in Vitro Anti-Metastatic Effects, International Journal of Molecular and Cellular Medicine (2017)
24. The Role of Probiotics in Cancer Treatment: Emphasis on Their in Vivo and in Vitro Anti-Metastatic Effects, International Journal of Molecular and Cellular Medicine (2017)
25. A Truncated Snail1 Transcription Factor Alters the Expression of Essential Emt Markers and Suppresses Tumor Cell Migration in a Human Lung Cancer Cell Line, Recent Patents on Anti-Cancer Drug Discovery (2019)
26. Advances in Natural Killer Cell Therapies for Breast Cancer, Immunology and Cell Biology (2023)
27. Piwi-Interacting Rnas: New Biomarkers for Diagnosis and Treatment of Breast Cancer, Cell and Bioscience (2020)
28. Epigenetics and Three Main Clinical Aspects of Breast Cancer Management, Epigenetics Territory and Cancer (2015)
29. Micrornas, Long Non-Coding Rnas, and Circular Rnas and Gynecological Cancers: Focus on Metastasis, Frontiers in Oncology (2023)
30. Investigation of Ccr7 Marker Expression Using Immunohistochemical Method and Its Association With Clinicopathologic Properties in Patients With Breast Cancer, International Journal of Hematology-Oncology and Stem Cell Research (2018)
31. Lung Cancer and Mirnas: A Possible Remedy for Anti-Metastatic, Therapeutic and Diagnostic Applications, Expert Review of Respiratory Medicine (2017)
32. Comparative Analysis of Protein-Protein Interaction Networks in Metastatic Breast Cancer, PLoS ONE (2022)
33. Epithelial-To-Mesenchymal Transition in Thyroid Cancer: A Comprehensive Review, Endocrine (2019)
34. Development of a 99Mtc-Labeled Cxcr4 Antagonist Derivative As a New Tumor Radiotracer, Cancer Biotherapy and Radiopharmaceuticals (2018)
35. The Potential of Circulating Tumor Cells in Personalized Management of Breast Cancer: A Systematic Review, Acta Medica Iranica (2017)
36. Harnessing Function of Emt in Cancer Drug Resistance: A Metastasis Regulator Determines Chemotherapy Response, Cancer and Metastasis Reviews (2024)
37. Maml1 and Twist1 Co-Overexpression Promote Invasion of Head and Neck Squamous Cell Carcinoma, Asia-Pacific Journal of Clinical Oncology (2018)
38. Role of Efna1 Snp (Rs12904) in Tumorigenesis and Metastasis of Colorectal Cancer: A Bioinformatic Analysis and Hrm Snp Genotyping Verification, Asian Pacific Journal of Cancer Prevention (2022)