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Comparative Analysis of Protein-Protein Interaction Networks in Metastatic Breast Cancer Publisher Pubmed



Hozhabri H1, 2, 3 ; Dehkohneh RSG2, 3, 4 ; Razavi SM2, 3, 5 ; Razavi SM2, 3, 5 ; Salarian F3, 7 ; Rasouli A3, 8 ; Azami J3, 9 ; Shiran MG2, 3, 10 ; Kardan Z3, 11 ; Farrokhzad N3, 12 ; Namini AM3, 13 ; Salari A2, 3, 14
Authors
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Authors Affiliations
  1. 1. Institute of Biochemistry and Biophysics, University of Tehran, Tehran, Iran
  2. 2. Salari Institute of Cognitive and Behavioral Disorders (SICBD), Alborz, Karaj, Iran
  3. 3. Systems Biology Research Lab, Bioinformatics Group, Systems Biology of the Next Generation Company (SBNGC), Qom, Iran
  4. 4. Department of Cell and Molecular Biology and Microbiology, Faculty of Biological Science and Technology, University of Isfahan, Isfahan, Iran
  5. 5. Department of Cell and Molecular Biology, Faculty of Biological Sciences, Kharazmi University, Tehran, Iran
  6. 6. Department of Chemical, Biomolecular and Corrosion Engineering, University of Akron, Akron, OH, United States
  7. 7. Department of Cellular Biotechnology, Cell Science Research Center, Royan Institute for Biotechnology, ACECR, Isfahan, Iran
  8. 8. Department of Toxicology and Pharmacology, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran
  9. 9. Faculty of Veterinary Medicine, Urmia University, Urmia, Iran
  10. 10. Department of Biology, Faculty of Sciences, Central Tehran Branch, Islamic Azad University, Tehran, Iran
  11. 11. Department of Cellular Molecular Biology, Faculty of Life Science and Biotechnology, Shahid Beheshti University, Tehran, Iran
  12. 12. Department of Biology, Faculty of Sciences, University of Guilan, Rasht, Iran
  13. 13. Department of Animal Biology, Faculty of Biological Sciences, Kharazmi University, Tehran, Iran
  14. 14. Department of Stem Cells and Developmental Biology, Cell Science Research Center, Royan Institute for Stem Cell Biology and Technology, ACECR, Tehran, Iran

Source: PLoS ONE Published:2022


Abstract

Metastatic lesions leading causes of the majority of deaths in patients with the breast cancer. The present study aimed to provide a comprehensive analysis of the differentially expressed genes (DEGs) in the brain (MDA-MB-231 BrM2) and lung (MDA-MB-231 LM2) metastatic cell lines obtained from breast cancer patients compared with those who have primary breast cancer. We identified 981 and 662 DEGs for brain and lung metastasis, respectively. Protein-protein interaction (PPI) analysis revealed seven shared (PLCB1, FPR1, FPR2, CX3CL1, GABBR2, GPR37, and CXCR4) hub genes between brain and lung metastasis in breast cancer. Moreover, GNG2 and CXCL8, C3, and PTPN6 in the brain and SAA1 and CCR5 in lung metastasis were found as unique hub genes. Besides, five co-regulation of clusters via seven important co-expression genes (COL1A2, LUM, SPARC, THBS2, IL1B, CXCL8, THY1) were identified in the brain PPI network. Clusters screening followed by biological process (BP) function and pathway enrichment analysis for both metastatic cell lines showed that complement receptor signalling, acetylcholine receptor signalling, and gastric acid secretion pathways were common between these metastases, whereas other pathways were site-specific. According to our findings, there are a set of genes and functional pathways that mark and mediate breast cancer metastasis to the brain and lungs, which may enable us understand the molecular basis of breast cancer development in a deeper levele to the brain and lungs, which may help us gain a more complete understanding of the molecular underpinnings of breast cancer development. © 2022 Hozhabri et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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