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Hesperidin Reduces Serum Levels of Triglyceride After Coronary Artery Bypass Graft Surgery Publisher



Booyani Z1 ; Aryaeian N1 ; Omidi N2 ; Khorasanian AS1 ; Hoseini AF3 ; Nejatian M4 ; Jazayeri S1 ; Morvaridi M1
Authors
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Authors Affiliations
  1. 1. Department of Nutrition, School of Public Health, Iran University of Medical Sciences, Tehran, Iran
  2. 2. Cardiac Primary Prevention Research Centre, Cardiovascular Disesae Research Institute, Tehran University of Medical Sciences, Tehran, Iran
  3. 3. Department of Biostatistics, School of Health, Iran University of Medical Sciences, Tehran, Iran
  4. 4. Department of Cardiac Rehabilitation, Tehran Heart Center, Tehran University of Medical Sciences, Tehran, Iran

Source: Food Science and Nutrition Published:2023


Abstract

Hesperidin, as an antioxidant and anti-inflammatory agent, has beneficial effects on cardiovascular diseases. This study aimed to determine the effects of hesperidin supplementation on inflammation, oxidative stress, and lipid profile in depressed coronary artery bypass graft surgery (CABG) patients. Eighty patients after coronary artery bypass graft surgery participated in this clinical trial and were randomly divided into two groups. The intervention group received 200 mg/d pure hesperidin supplement and the second group received placebo for 12 weeks. Both groups continued their usual diet. Serum concentrations of inflammatory and stress oxidative markers (hs-CRP, P-selectin, and ox-LDL) were measured and compared at baseline and the end of the intervention. The changes in serum levels of triglyceride were significantly different between the two groups (p <.05). HDL-c significantly increased in groups but the differences between the two groups were not statistically significant (p >.05). Hesperidin did not affect FBS, other lipid parameters, hs-CRP, P-selectin, and OX-LDL (p >.05). SBP and DBP differences were not statistically significant (p >.05). After 12 weeks of intervention, hesperidin reduced serum levels of triglyceride in depressed post-CABG patients. © 2023 The Authors. Food Science & Nutrition published by Wiley Periodicals LLC.
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