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Factors Associated With Mortality in Covid-19 Patients: A Systematic Review and Meta-Analysis Publisher



Sepandi M1, 2 ; Taghdir M1 ; Alimohamadi Y3, 4 ; Afrashteh S5, 6 ; Hosamirudsari H7
Authors
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Authors Affiliations
  1. 1. Health Research Center, Life Style Institute, Baqiyatallah University of Medical Sciences, Tehran, Iran
  2. 2. Department of Epidemiology & Biostatistics, School of Health, Baqiyatallah University of Medical Sciences, Tehran, Iran
  3. 3. Pars Advanced and Minimally Invasive Medical Manners Research Center, Pars Hospital, Iran University of Medical Sciences, Tehran, Iran
  4. 4. Department of Epidemiology & Biostatistics, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran
  5. 5. Department of Public Health, Faculty of Health, Bushehr University of Medical Sciences, Bushehr, Iran
  6. 6. Research Committee, Shiraz University of Medical Sciences, Shiraz, Iran
  7. 7. Department of Infectious Diseases, Baharloo Hospital, Tehran University of Medical Sciences, Tehran, Iran

Source: Iranian Journal of Public Health Published:2020


Abstract

Background: The current study aimed to identify effective factors on the death among COVID-19 patients. Methods: All articles published in the period Jan 1, 2020, to Mar 23, 2020, written in English and reporting fac-tors associated with COVID-19 mortality were reviewed. The random-effects model with 95% CI was used to calculate the pooled Odds Ratio (OR) and Hazard Ratio (HR). Data were analyzed using Stata ver.11.0. Results: The older age OR: 1.21(1.10-1.33) and male gender OR: 1.41(1.04-1.89) were most prone to death due to COVID-19. The Comorbidity with some chronic diseases such as Diabetes type2 OR: 2.42(1.06-5.52), Hy-pertension OR: 2.54(1.21-5.32), Kidney disorder OR: 2.61(1.22-5.60), Respiratory disorder 3.09 (1.39-6.88) and Heart diseases OR: 4.37 (1.13-16.90) can increase the risk of COVID19 mortality. Conclusion: Infection with COVID-19 is associated with substantial mortality mainly in older patients with comorbidities. We found the significant effect of age, gender and comorbidities such as Diabetes Mellitus, Hy-pertension, Kidney disorders and Heart diseases on the risk of death in patients with COVID-19. The factors associated with mortality found in this research can help to recognize patients with COVID-19 who are at high-er risk of a poor prognosis. Monitoring these factors can serve to give early warning for the appropriate inter-ventions. © 2020, Iranian Journal of Public Health. All rights reserved.
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