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Lipid Variability and Risk of Microvascular Complications in Patients With Diabetes: A Systematic Review and Meta-Analysis Publisher Pubmed



Karimi MA1 ; Vaezi A2 ; Ansari A3 ; Archin I4 ; Dadgar K5 ; Rasouli A6 ; Ghannadikhosh P7 ; Alishiri G8 ; Tizro N9 ; Gharei F1 ; Imanparvar S10 ; Salehi S11 ; Mazhari SA12 ; Etemadi MH13 Show All Authors
Authors
  1. Karimi MA1
  2. Vaezi A2
  3. Ansari A3
  4. Archin I4
  5. Dadgar K5
  6. Rasouli A6
  7. Ghannadikhosh P7
  8. Alishiri G8
  9. Tizro N9
  10. Gharei F1
  11. Imanparvar S10
  12. Salehi S11
  13. Mazhari SA12
  14. Etemadi MH13
  15. Alipour M14
  16. Deravi N1
  17. Naziri M15
Show Affiliations
Authors Affiliations
  1. 1. School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  2. 2. Student Research Committee, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
  3. 3. Medical Student, Shantou University Medical College, Guangdong, Shantou, China
  4. 4. Kazan (Volga Region) Federal University, Kazan, Russian Federation
  5. 5. Young Researchers Elite Club, Islamic Azad University Tehran Medical Branch, Tehran, Iran
  6. 6. School of Medicine, Zanjan University of Medical Sciences, Zanjan, Iran
  7. 7. Student Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran
  8. 8. Students Research Committee, School of Medicine, Ardabil University of Medical Sciences, Ardabil, Iran
  9. 9. Student Research Committee, School of Medicine, Guilan University of Medical Sciences, Rasht, Iran
  10. 10. School of Medicine, Ardabil University of Medical Sciences, Ardabil, Iran
  11. 11. Department of Medicine, Ardabil Medical Sciences Branch, Islamic Azad University, Ardabil, Iran
  12. 12. Student Research Committee, Azerbaijan Medical University, Baku, Azerbaijan
  13. 13. School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
  14. 14. Medical Student, Department of Medicine, Islamic Azad University Tehran Medical Sciences, Tehran, Iran
  15. 15. Students Research Committee, School of Medicine, Iran University of Medical Sciences, Tehran, Iran

Source: BMC Endocrine Disorders Published:2024


Abstract

Background and aims: The current systematic review aimed to elucidate the effects of lipid variability on microvascular complication risk in diabetic patients. The lipid components studied were as follows: High-density lipoprotein (HDL), High-density lipoprotein (LDL), Triglyceride (TG), Total Cholesterol (TC), and Remnant Cholesterol (RC). Method: We carried out a systematic search in multiple databases, including PubMed, Web of Science, and SCOPUS, up to October 2nd, 2023. After omitting the duplicates, we screened the title and abstract of the studies. Next, we retrieved and reviewed the full text of the remaining articles and included the ones that met our inclusion criteria in the study. Result: In this research, we examined seven studies, comprising six cohort studies and one cross-sectional study. This research was conducted in Hong Kong, China, Japan, Taiwan, Finland, and Italy. The publication years of these articles ranged from 2012 to 2022, and the duration of each study ranged from 5 to 14.3 years. The study group consisted of patients with type 2 diabetes aged between 45 and 84 years, with a diabetes history of 7 to 12 years. These studies have demonstrated that higher levels of LDL, HDL, and TG variability can have adverse effects on microvascular complications, especially nephropathy and neuropathic complications. TG and LDL variability were associated with the development of albuminuria and GFR decline. Additionally, reducing HDL levels showed a protective effect against microalbuminuria. However, other studies did not reveal an apparent relationship between lipid variations and microvascular complications, such as retinopathy. Current research lacks geographic and demographic diversity. Increased HDL, TG, and RC variability have been associated with several microvascular difficulties. Still, the pathogenic mechanism is not entirely known, and understanding how lipid variability affects microvascular disorders may lead to novel treatments. Furthermore, the current body of this research is restricted in its coverage. This field's lack of thorough investigations required a more extensive study and comprehensive effort. Conclusion: The relationship between lipid variation (LDL, HDL, and TG) (adverse effects) on microvascular complications, especially nephropathy and neuropathic (and maybe not retinopathy), is proven. Physicians and health policymakers should be highly vigilant to lipid variation in a general population. © 2023, The Author(s).
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