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Lipoprotein (A) As a Predictor of Diabetic Retinopathy in Patients With Type 2 Diabetes: A Systematic Review Publisher Pubmed



Gholami Chahkand MS1 ; Esmaeilpour Moallem F2 ; Qezelgachi A3 ; Seifouri K4 ; Pesaran Afsharian A5 ; Sheikhzadeh F6 ; Poursalehi A7 ; Fani Sadrabadi FS8 ; Saghab Torbati M9 ; Ramezanzade M10 ; Alishiri G11 ; Ansari A12 ; Zare Dehabadi E4 ; Karimi Matloub S13 Show All Authors
Authors
  1. Gholami Chahkand MS1
  2. Esmaeilpour Moallem F2
  3. Qezelgachi A3
  4. Seifouri K4
  5. Pesaran Afsharian A5
  6. Sheikhzadeh F6
  7. Poursalehi A7
  8. Fani Sadrabadi FS8
  9. Saghab Torbati M9
  10. Ramezanzade M10
  11. Alishiri G11
  12. Ansari A12
  13. Zare Dehabadi E4
  14. Karimi Matloub S13
  15. Sheikh Z14
  16. Deravi N4
  17. Mehrtabar S15
  18. Chichagi F16
  19. Faal Hamedanchi N17
  20. Arzaghi M18
  21. Asadi M19
  22. Alsadat Dadkhah P3
  23. Ansari A12
Show Affiliations
Authors Affiliations
  1. 1. Student Research Committee, School of Medicine, Zahedan University of Medical Sciences, Zahedan, Iran
  2. 2. Student Research Committee, Golestan University of Medical Sciences, Gorgan, Iran
  3. 3. Student Research Committee, Qazvin University of Medical Sciences, Qazvin, Iran
  4. 4. Student Research Committee, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  5. 5. Student Research Committee, Urmia University of Medical Sciences, Urmia, Iran
  6. 6. Student Research Committee, School of Medicine, Iran University of Medical Sciences, Tehran, Iran
  7. 7. Student Research Committee, School of Paramedical, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  8. 8. Student Research Committee, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
  9. 9. Islamic Azad University of Zahedan, Zahedan, Iran
  10. 10. School of Medicine, Guilan University of Medical Sciences, Rasht, Iran
  11. 11. Students Research Committee, School of Medicine, Ardabil University of Medical Sciences, Ardabil, Iran
  12. 12. Student Research Committee, School of Medicine, North Khorasan University of Medical Sciences, Bojnurd, Iran
  13. 13. Students Research Committee, Qom University of Medical Sciences, Qom, Iran
  14. 14. Student Research Committee, School of Medicine, Babol University of Medical Sciences, Babol, Iran
  15. 15. Student Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran
  16. 16. Students’ Scientific Research Center (SSRC), Tehran University of Medical Sciences, Tehran, Iran
  17. 17. Faculty of Medicine, Islamic Azad University, Tehran Medical Sciences Branch, Tehran, Iran
  18. 18. Shahid Beheshti University of Medical Sciences, Tehran, Iran
  19. 19. Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
  20. 20. Medical College, Shantou University, Shantou, China

Source: Diabetes and Vascular Disease Research Published:2023


Abstract

Background: Lipoprotein a (LP(a)), an LDL-like lipoprotein, known as a risk factor for cardiovascular diseases, has a controversial association with diabetic retinopathy in patients with type 2 diabetes—the current systematic review aimed to critically assess the association between LP(a) and diabetic retinopathy. Methods: A systematic review of relevant studies was conducted after a thorough search in PubMed, Scopus, and Google Scholar electronic databases. We used English observational, case-control, and prospective cohort studies published up to August 2022, including type 2 diabetic patients as the population, diabetic retinopathy as the outcome, and LP(a) as the intervention. Result: 17 relevant studies, including 4688 patients with diabetes, were included in this systematic review. While in 13 studies, Lipoprotein(a) was recognized as a risk factor for diabetic retinopathy, only three studies reported no evidence of a relationship between the two. Also, another study showed a mixed outcome of the relationship between LP(a) and diabetic retinopathy. Conclusion: High serum lipoprotein(a) in patients with type 2 diabetes is considered a risk factor for diabetic retinopathy. However, further large-scaled cohort studies are still required to validate this finding. © The Author(s) 2023.
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