Tehran University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
Immunomodulatory Effects of Nanocurcumin on Th17 Cell Responses in Mild and Severe Covid-19 Patients Publisher Pubmed



Tahmasebi S1 ; Elesawi MA2 ; Mahmoud ZH3 ; Timoshin A4 ; Valizadeh H5 ; Roshangar L6 ; Varshoch M7 ; Vaez A7 ; Aslani S8 ; Navashenaq JG9 ; Aghebatimaleki L10 ; Ahmadi M6
Authors
Show Affiliations
Authors Affiliations
  1. 1. Department of Immunology, Healthy Faculty, Tehran University of Medical Sciences, Tehran, Iran
  2. 2. Department of Botany, Faculty of Science, Tanta University, Tanta, Egypt
  3. 3. Department of Chemistry, College of Science, Diyala University, Baquba, Iraq
  4. 4. Department of Propaedeutics of Dental Diseases, I. M. Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russian Federation
  5. 5. Tuberculosis and Lung Disease Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
  6. 6. Stem Cell Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
  7. 7. Infectious and Tropical Diseases Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
  8. 8. Department of Immunology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
  9. 9. Noncommunicable Diseases Research Center, Bam University of Medical Sciences, Bam, Iran
  10. 10. Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran

Source: Journal of Cellular Physiology Published:2021


Abstract

In novel coronavirus disease 2019 (COVID-19), the increased frequency and overactivation of T helper (Th) 17 cells and subsequent production of large amounts of proinflammatory cytokines result in hyperinflammation and disease progression. The current study aimed to investigate the therapeutic effects of nanocurcumin on the frequency and responses of Th17 cells in mild and severe COVID-19 patients. In this study, 40 severe COVID-19 intensive care unit-admitted patients and 40 patients in mild condition were included. The frequency of Th17 cells, the messenger RNA expression of Th17 cell-related factors (RAR-related orphan receptor γt, interleukin [IL]-17, IL-21, IL-23, and granulocyte-macrophage colony-stimulating factor), and the serum levels of cytokines were measured in both nanocurcumin and placebo-treated groups before and after treatment. A significant decrease in the number of Th17 cells, downregulation of Th17 cell-related factors, and decreased levels of Th17 cell-related cytokines were found in mild and severe COVID-19 patients treated by nanocurcumin compared to the placebo group. Moreover, the abovementioned parameters were significantly decreased in the nanocurcumin-treated group after treatment versus before treatment. Curcumin could reduce the frequency of Th17 cells and their related inflammatory factors in both mild and severe COVID-19 patients. Hence, it could be considered as a potential modulatory compound in improving the patient's inflammatory condition. © 2020 Wiley Periodicals LLC
Related Docs
View other Related Docs
1. Nanocurcumin Improves Treg Cell Responses in Patients With Mild and Severe Sars-Cov2, Life Sciences (2021)
2. Nanocurcumin Modulates Th17 Cell Responses in Moderate and Severe Copd Patients, Heliyon (2024)
3. Th17 and Treg Cells Function in Sars-Cov2 Patients Compared With Healthy Controls, Journal of Cellular Physiology (2021)
4. Risk Factors for Adverse Outcomes of Covid-19 Patients: Possible Basis for Diverse Responses to the Novel Coronavirus Sars-Cov-2, Life Sciences (2021)
5. Covid-19: Our Current Knowledge of Epidemiology, Pathology, Therapeutic Approaches, and Diagnostic Methods, Anti-Cancer Agents in Medicinal Chemistry (2021)
6. Recent Advances in Antibody-Based Immunotherapy Strategies for Covid-19, Journal of Cellular Biochemistry (2021)
7. Oral Nano-Curcumin Formulation Efficacy in Management of Mild to Moderate Hospitalized Coronavirus Disease-19 Patients: An Open Label Nonrandomized Clinical Trial, Phytotherapy Research (2021)
8. The Effects of Oxygen–Ozone Therapy on Regulatory T-Cell Responses in Multiple Sclerosis Patients, Cell Biology International (2021)
Experts (# of related papers)
View all Related Experts
Nima Rezaei (17)
Alireza Abdollahi (3)
Other Related Docs
9. Cancer Care Management During the Covid-19 Pandemic, Risk Management and Healthcare Policy (2020)
10. A Review of Covid-19: The Main Ways of Transmission and Some Prevention Solutions, Clinical Symptoms, More Vulnerable Human Groups, Risk Factors, Diagnosis, and Treatment, Journal of Environmental Treatment Techniques (2020)
11. Immune-Based Therapy for Covid-19, Advances in Experimental Medicine and Biology (2021)
12. A Review on Currently Available Potential Therapeutic Options for Covid-19, International Journal of General Medicine (2020)
13. Biomarker Based Biosensors: An Opportunity for Diagnosis of Covid-19, Reviews in Medical Virology (2022)
14. Changes in Th17 Cells Frequency and Function After Ozone Therapy Used to Treat Multiple Sclerosis Patients: Ozone Therapy Uses to Treat Multiple Sclerosis Patients, Multiple Sclerosis and Related Disorders (2020)
15. Oral Nano-Curcumin Formulation Efficacy in the Management of Mild to Moderate Outpatient Covid-19: A Randomized Triple-Blind Placebo-Controlled Clinical Trial, Food Science and Nutrition (2021)
16. Severe Acute Respiratory Syndrome-Coronavirus-2 Spike (S) Protein Based Vaccine Candidates: State of the Art and Future Prospects, Reviews in Medical Virology (2021)
17. World One-Hundred Days After Covid-19 Outbreak: Incidence, Case Fatality Rate, and Trend, Journal of Education and Health Promotion (2020)
18. Early Versus Late Tracheostomy in Mechanically Ventilated Covid-19 Patients: A Comparative Study, Acta Medica Iranica (2023)
19. Molecular Dynamics Analysis Predicts Ritonavir and Naloxegol Strongly Block the Sars-Cov-2 Spike Protein-Hace2 Binding, Journal of Biomolecular Structure and Dynamics (2022)
20. The Contributory Role of Lymphocyte Subsets, Pathophysiology of Lymphopenia and Its Implication As Prognostic and Therapeutic Opportunity in Covid-19, International Immunopharmacology (2021)
21. The Outlook for Diagnostic Purposes of the 2019-Novel Coronavirus Disease, Journal of Cellular Physiology (2020)
22. The Immune System As a Target for Therapy of Sars-Cov-2: A Systematic Review of the Current Immunotherapies for Covid-19, Life Sciences (2020)
23. Immunology, Immunopathogenesis and Immunotherapeutics of Covid-19; an Overview, International Immunopharmacology (2021)
24. An Overview on the Treatments and Prevention Against Covid-19, Virology Journal (2023)
25. Variants in Ace2; Potential Influences on Virus Infection and Covid-19 Severity, Infection# Genetics and Evolution (2021)
26. A Review on the Mechanisms Involved in the Immunopathogenesis of Sars-Cov-2, Journal of Military Medicine (2020)
27. Nano-Curcumin Therapy, a Promising Method in Modulating Inflammatory Cytokines in Covid-19 Patients, International Immunopharmacology (2020)
28. Covid-19 Infection and Liver Injury: Clinical Features, Biomarkers, Potential Mechanisms, Treatment, and Management Challenges, World Journal of Clinical Cases (2021)
29. Covid-19: Review of a 21St Century Pandemic From Etiology to Neuro-Psychiatric Implications, Journal of Alzheimer's Disease (2020)
30. The Immunological Therapeutic Strategies for Controlling Multiple Sclerosis: Considerations During the Covid-19 Pandemic, Biomolecules (2021)
31. Evaluation of Mir-200C-3P and Mir-421-5P Levels During Immune Responses in the Admitted and Recovered Covid-19 Subjects, Infection# Genetics and Evolution (2022)
32. Naringenin, a Flavanone With Antiviral and Anti-Inflammatory Effects: A Promising Treatment Strategy Against Covid-19, Phytotherapy Research (2020)
33. Immunophenotyping Characteristics of Covid-19 Patients: Peripheral Blood Cd8+ Hla-Dr+ T Cells As a Biomarker for Mortality Outcome, Journal of Medical Virology (2023)
34. Cardiovascular Diseases Burden in Covid-19: Systematic Review and Meta-Analysis, American Journal of Emergency Medicine (2021)
35. Novel Therapeutic Approaches for Treatment of Covid-19, Journal of Molecular Medicine (2020)
36. Epidemiological and Clinical Characteristics of Covid-19 Patients Studied by Jiroft University of Medical Sciences: Southeast of Iran, Journal of Advances in Medical and Biomedical Research (2021)
37. The Possible Role of Novel Coronavirus 2019 Proteins in the Development of Drugs and Vaccines, Journal of Applied Biotechnology Reports (2020)
38. Coagulopathy and Thromboembolic Events a Pathogenic Mechanism of Covid-19 Associated With Mortality: An Updated Review, Journal of Clinical Laboratory Analysis (2023)
39. Estimate of the Basic Reproduction Number for Covid-19: A Systematic Review and Meta-Analysis, Journal of Preventive Medicine and Public Health (2020)
40. The Association Between Cardiac Injury and Outcomes in Hospitalized Patients With Covid-19, Internal and Emergency Medicine (2020)
41. Impact of Sars-Cov-2 Pandemic on Patients With Primary Immunodeficiency, Journal of Clinical Immunology (2021)
42. Photobiomodulation and Antiviral Photodynamic Therapy in Covid-19 Management, Advances in Experimental Medicine and Biology (2021)
43. Immune Profiling of Sars-Cov-2; What We Know and What We Don’T Know, Iranian Journal of Allergy# Asthma and Immunology (2023)
44. Sars-Cov-2 and Covid-19, Evidence From a Literature Review: Review Article, Tehran University Medical Journal (2021)
45. A Review on an Ongoing Pandemic Caused by the Severe Acute Respiratory Syndrome Coronavirus 2: The Pathogenesis, Epidemiology, Immunological Features, and Currently Available Diagnostic Tests, Reviews and Research in Medical Microbiology (2022)
46. Covid-19 and Multiorgan Failure: A Narrative Review on Potential Mechanisms, Journal of Molecular Histology (2020)
47. The Chimera of S1 and N Proteins of Sars-Cov-2: Can It Be a Potential Vaccine Candidate for Covid-19?, Expert Review of Vaccines (2022)
48. Gastrointestinal Symptoms in Patients With Mild and Severe Covid-19: A Scoping Review and Meta-Analysis, Gastroenterology and Hepatology from Bed to Bench (2020)
49. Crispr/Cas13: A Potential Therapeutic Option of Covid-19, Biomedicine and Pharmacotherapy (2020)
50. Curcumin: A Modulator of Inflammatory Signaling Pathways in the Immune System, Inflammopharmacology (2019)