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The Effects of Oxygen–Ozone Therapy on Regulatory T-Cell Responses in Multiple Sclerosis Patients Publisher Pubmed



Tahmasebi S1 ; Qasim MT2 ; Krivenkova MV3 ; Zekiy AO4 ; Thangavelu L4 ; Aravindhan S5 ; Izadi M6 ; Jadidiniaragh F8 ; Ghaebi M7 ; Aslani S9 ; Aghebatmaleki L8 ; Ahmadi M7 ; Roshangar L7
Authors

Source: Cell Biology International Published:2021


Abstract

Multiple sclerosis (MS) is a common degenerative disorder of the central nervous system. The decreased frequency and dysfunction of Treg cells cause inflammation and disease progression. Ozone autohemotherapy can be used as a potential therapeutic approach to regulate the immune system responses and inflammation in MS. For this purpose, 20 relapsing-remitting multiple sclerosis patients were under treatment with ozone twice weekly for 6 months. The frequency of Treg cell, the expression levels of the Treg cell-related factors (FoxP3, IL-10, TGF-β, miR-17, miR-27, and miR-146A), and the secretion levels of IL-10 and TGF-β were assessed. We found a significant increase in the number of Treg cells, expression levels of FoxP3, miRNAs (miR-17 and miR-27), IL-10, and TGF-β factors in patients after oxygen–ozone (O2-O3) therapy compared to before treatment. In contrast, oxygen–ozone therapy notably decreased the expression level of miR-146a in treated patients. Interestingly, the secretion levels of both IL-10 and TGF-β cytokines were considerably increased in both serum and supernatant of cultured peripheral blood mononuclear cells in posttreatment condition compared to pretreatment condition. According to results, oxygen–ozone therapy raised the frequency of Treg cell and its relevant factors in treated MS patients. Oxygen–ozone therapy would contribute to improving the MS patients by elevating the Treg cell responses. © 2021 International Federation for Cell Biology
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