Nano-Curcumin Therapy, a Promising Method in Modulating Inflammatory Cytokines in Covid-19 Patients

Nano-Curcumin Therapy, a Promising Method in Modulating Inflammatory Cytokines in Covid-19 Patients Publisher Pubmed

Valizadeh H^{1, 2} ; Abdolmohammadivahid S^{3, 4} ; Danshina S⁵ ; Ziya Gencer M⁶ ; Ammari A⁷ ; Sadeghi A^{1, 2} ; Roshangar L⁴ ; Aslani S⁸ ; Esmaeilzadeh A⁹ ; Ghaebi M⁹ ; Valizadeh S² ; Ahmadi M⁴

Show Affiliations

1. Tuberculosis and Lung Disease Research Center of Tabriz University of Medical Sciences, Tabriz, Iran
2. Department of Internal Medicine, School of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran
3. Student's Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran
4. Stem Cell Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
5. Department of propaedeutics of dental diseases, I.M. Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russian Federation
6. Department of Family Medicine, Yassawi International Kazakh-Turkish University Hospital, Turkistan, Kazakhstan
7. Department of Surgery, Mousavi Hospital, School of Medicine, Zanjan University of Medical Sciences, Zanjan, Iran
8. Department of Immunology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
9. Cancer Gene Therapy Research Center (CGRC), Zanjan University of Medical Sciences, Zanjan, Iran

Source: International Immunopharmacology Published:2020

Abstract

Background: As an ongoing worldwide health issue, Coronavirus disease 2019 (COVID–19) has been causing serious complications, including pneumonia, acute respiratory distress syndrome (ARDS), and multi-organ failure. However, there is no decisive treatment approach available for this disorder, which is primarily attributed to the large amount of inflammatory cytokine production. We aimed to identify the effects of Nano-curcumin on the modulation of inflammatory cytokines in COVID-19 patients. Method: Forty COVID-19 patients and 40 healthy controls were recruited and evaluated for inflammatory cytokine expression and secretion. Subsequently, COVID-19 patients were divided into two groups: 20 patients receiving Nano-curcumin and 20 patients as the placebo group. The mRNA expression and cytokine secretion levels of IL-1β, IL-6, TNF-α and IL‐18 were assessed by Real‐time PCR and ELISA, respectively. Result: Our primary results indicated that the mRNA expression and cytokine secretion of IL-1β, IL-6, TNF-α, and IL-18 were increased significantly in COVID-19 patients compared with healthy control group. After treatment with Nano-curcumin, a significant decrease in IL-6 expression and secretion in serum and in supernatant (P = 0.0003, 0.0038, and 0.0001, respectively) and IL-1β gene expression and secretion level in serum and supernatant (P = 0.0017, 0.0082, and 0.0041, respectively) was observed. However, IL-18 mRNA expression and TNF-α concentration were not influenced by Nano-curcumin. Conclusion: Nano-curcumin, as an anti-inflammatory herbal based agent, may be able to modulate the increased rate of inflammatory cytokines especially IL-1β and IL-6 mRNA expression and cytokine secretion in COVID-19 patients, which may cause an improvement in clinical manifestation and overall recovery. © 2020

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Style	Citing Format
MLA	Valizadeh H, et al.. "Nano-Curcumin Therapy, a Promising Method in Modulating Inflammatory Cytokines in Covid-19 Patients." International Immunopharmacology, vol. 89, no. , 2020, pp. -.
APA	Valizadeh H, Abdolmohammadivahid S, Danshina S, Ziya Gencer M, Ammari A, Sadeghi A, Roshangar L, Aslani S, Esmaeilzadeh A, Ghaebi M, Valizadeh S, Ahmadi M (2020). Nano-Curcumin Therapy, a Promising Method in Modulating Inflammatory Cytokines in Covid-19 Patients. International Immunopharmacology, 89(), -.
Chicago	Valizadeh H, Abdolmohammadivahid S, Danshina S, Ziya Gencer M, Ammari A, Sadeghi A, Roshangar L, et al.. "Nano-Curcumin Therapy, a Promising Method in Modulating Inflammatory Cytokines in Covid-19 Patients." International Immunopharmacology 89, no. (2020): -.
Harvard	Valizadeh H et al. (2020) 'Nano-Curcumin Therapy, a Promising Method in Modulating Inflammatory Cytokines in Covid-19 Patients', International Immunopharmacology, 89(), pp. -.
Vancouver	Valizadeh H, Abdolmohammadivahid S, Danshina S, Ziya Gencer M, Ammari A, Sadeghi A, et al.. Nano-Curcumin Therapy, a Promising Method in Modulating Inflammatory Cytokines in Covid-19 Patients. International Immunopharmacology. 2020;89():-.
BibTex	@article{ author = {Valizadeh H and Abdolmohammadivahid S and Danshina S and Ziya Gencer M and Ammari A and Sadeghi A and Roshangar L and Aslani S and Esmaeilzadeh A and Ghaebi M and Valizadeh S and Ahmadi M}, title = {Nano-Curcumin Therapy, a Promising Method in Modulating Inflammatory Cytokines in Covid-19 Patients}, journal = {International Immunopharmacology}, volume = {89}, number = {}, pages = {-}, year = {2020} }
RIS	TY - JOUR AU - Valizadeh H AU - Abdolmohammadivahid S AU - Danshina S AU - Ziya Gencer M AU - Ammari A AU - Sadeghi A AU - Roshangar L AU - Aslani S AU - Esmaeilzadeh A AU - Ghaebi M AU - Valizadeh S AU - Ahmadi M TI - Nano-Curcumin Therapy, a Promising Method in Modulating Inflammatory Cytokines in Covid-19 Patients JO - International Immunopharmacology VL - 89 IS - SP - EP - PY - 2020 ER -

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