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Assessment of Abdominal Fat Distribution in Non-Alcoholic Fatty Liver Disease by Magnetic Resonance Imaging: A Population-Based Study Pubmed



Radmard AR1, 2 ; Rahmanian MS2 ; Abrishami A1 ; Yoonessi A2, 3 ; Kooraki S1 ; Dadgostar M4 ; Hashemi Taheri AP1 ; Gerami Seresht M1 ; Poustchi H5 ; Jafari E5 ; Malekzadeh R5 ; Merat S5
Authors
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Authors Affiliations
  1. 1. Department of Radiology, Shariati hospital, Tehran University of Medical Sciences, North Kargar Ave., Tehran, 14114, Iran
  2. 2. Digestive Tract Image Processing Research Group, Digestive Diseases Research Institute, Tehran University of Medical Sciences, North Kargar Ave., Tehran, 14117-13135, Iran
  3. 3. Neuroscience Department, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran, Iran
  4. 4. Department of Biomedical Engineering, Central Tehran Branch, Islamic Azad University, Tehran, Iran
  5. 5. Liver and Pancreatobiliary Diseases Research Center, Digestive Diseases Research Institute, Tehran University of Medical Sciences, Tehran, 14117-13135, Iran

Source: Archives of Iranian Medicine Published:2016


Abstract

Background: To investigate the association between non-alcoholic fatty liver disease (NAFLD) and quantitative measures of central adiposity in the general population using a semi-automated method on magnetic resonance imaging (MRI) data. Methods: Subjects were recruited from Golestan Cohort Study. Two groups of 120 individuals with and without fatty liver were randomly selected based on findings of ultrasound. Non-invasive diagnosis of NAFLD was made by combination of ultrasound and MRI. Various anthropometric indices including body mass index (BMI), waist-to-hip ratio (WHR) and waist-to-height ratio (WHtR) were measured. Segmentation and calculation of visceral (VFA) and subcutaneous fat area (SFA) were performed on three levels of MRI slices using semi-automated software. Results: Atotal of 109 individuals fulfilled the NAFLD criteria, while 92 subjects were selected as the control group. All obesity measures, except for SFA, were significantly higher in subjects with NAFLD compared to controls. Significant associations were found between NAFLD and adiposity indices, except for SFA, with the highest odds ratio observed in WHR (OR: 3.37, CI: 1.40-3.70, P< 0.001). VFA also had the greatest correlation with ultrasound (r = 0.523, P < 0.001) and MRI (r = 0.546, P < 0.001) indicators of NAFLD. Conclusions: Quantitative measures of visceral adiposity are associated with NAFLD, while subcutaneous fat measures are poor indicators for identifying NAFLD. Compared to conventional anthropometric indices, VFA best correlates with ultrasound and MRI criteria of fatty liver. © 2016, Academy of Medical Sciences of I.R. Iran. All rights reserved.
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