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Differential Expression of Mir-192, Mir-221, Mir-15 Among the Nodule Tissues of Sarcoidosis and Lung Cancer Publisher



Varaei SSR1 ; Mohamadnia A2 ; Movahedi M1 ; Bahrami N3, 4 ; Shirian S5, 6
Authors
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Authors Affiliations
  1. 1. Department of Biochemistry, Faculty of Biological Sciences, North Tehran Branch, Islamic Azad University, Tehran, Iran
  2. 2. Chronic Respiratory Diseases Research Center, NRITLD, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  3. 3. Department of Tissue Engineering and Applied Cell Sciences, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran, Iran
  4. 4. Craniomaxillofacial Research Center, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran
  5. 5. Department of Pathology, School of Veterinary Medicine, Shahrekord University, Shahrekord, Iran
  6. 6. Dr Daneshbod Pathology Laboratory, Shiraz Molecular Pathology Research Center, Shiraz, Iran

Source: International Journal of Cancer Management Published:2024


Abstract

Background: Patients with sarcoidosis were found to have a higher risk of lung cancer compared to the general population. Being aware of all possible associations between these two diseases and identification of biomarkers such as miRNA profiles can be helpful in differentiating the mechanisms of these two diseases, which can aid in clinical decision-making. Methods: The aim of the study was to investigate the expression of selected miRNAs (miR-192 miR-221, miR-15) in lymph nodes of patients with pulmonary sarcoidosis, non-small cell lung carcinomas (NSCLC) and control group (n = 30 per groups) by qRT-PCR. Results: Relative expression of miR-221 in sarcoidosis and NSCC patients was higher than in the control group. Furthermore, the relative expression of miR-15 in patients with sarcoidosis and NSCLC tissue was lower than in the control group. Interestingly, miR-192 is differentially expressed in sarcoidosis and NSCLC patients compared to the control group. Conclusions: The obtained results suggest that the studied miRNAs may have potential diagnostic and therapeutic implications, but further research is necessary to fully understand their roles in these diseases. © 2025, Rasi Varaei et al.