Design, Synthesis, in Vivo, and in Silico Studies of New [1,2,4] Triazolo[1,5-A]Pyrimidine-7(4H)-One Derivatives As Potent Anticonvulsant Agents

Design, Synthesis, in Vivo, and in Silico Studies of New [1,2,4] Triazolo[1,5-A]Pyrimidine-7(4H)-One Derivatives As Potent Anticonvulsant Agents Publisher

Fallah Kolamsary M ; Kabirifard H ; Dehpour A R ; Mahdavi M ; Mohammadi Khanaposhtani M

Source: Monatshefte fur Chemie Published:2026

Abstract

A new series of [1,2,4]triazolo[1,5-a]pyrimidine-7(4H)-one derivatives was designed, synthesized, and evaluated as potent anticonvulsant agents in pentylenetetrazole (PTZ) and maximal electroshock (MES) induced seizure models in mice. Latency times to the first symptom of seizure were measured, and the recorded data demonstrated that most of the newly synthesized compounds exhibited anticonvulsant activity in the PTZ test. Among them, the 4-bromobenzyl derivative showed the best anticonvulsant activity and was also the most potent compound in the MES assay. Considering that the new scaffold possesses the necessary pharmacophore units to act as a benzodiazepine receptor (BZDR) agonist, this most potent derivative was further evaluated in vivo and in silico for BZDR agonist activity. The in vivo evaluation using flumazenil, a BZDR antagonist, confirmed agonist action of the most potent compound at the BZDR. © Springer-Verlag GmbH Austria, part of Springer Nature 2026.

Style	Citing Format
MLA	Fallah Kolamsary M, et al.. "Design, Synthesis, in Vivo, and in Silico Studies of New [1,2,4] Triazolo[1,5-A]Pyrimidine-7(4H)-One Derivatives As Potent Anticonvulsant Agents." Monatshefte fur Chemie, vol. 157, no. 7, 2026, pp. 1035-1045.
APA	Fallah Kolamsary M, Kabirifard H, Dehpour A R, Mahdavi M, Mohammadi Khanaposhtani M (2026). Design, Synthesis, in Vivo, and in Silico Studies of New [1,2,4] Triazolo[1,5-A]Pyrimidine-7(4H)-One Derivatives As Potent Anticonvulsant Agents. Monatshefte fur Chemie, 157(7), 1035-1045.
Chicago	Fallah Kolamsary M, Kabirifard H, Dehpour A R, Mahdavi M, Mohammadi Khanaposhtani M. "Design, Synthesis, in Vivo, and in Silico Studies of New [1,2,4] Triazolo[1,5-A]Pyrimidine-7(4H)-One Derivatives As Potent Anticonvulsant Agents." Monatshefte fur Chemie 157, no. 7 (2026): 1035-1045.
Harvard	Fallah Kolamsary M et al. (2026) 'Design, Synthesis, in Vivo, and in Silico Studies of New [1,2,4] Triazolo[1,5-A]Pyrimidine-7(4H)-One Derivatives As Potent Anticonvulsant Agents', Monatshefte fur Chemie, 157(7), pp. 1035-1045.
Vancouver	Fallah Kolamsary M, Kabirifard H, Dehpour A R, Mahdavi M, Mohammadi Khanaposhtani M. Design, Synthesis, in Vivo, and in Silico Studies of New [1,2,4] Triazolo[1,5-A]Pyrimidine-7(4H)-One Derivatives As Potent Anticonvulsant Agents. Monatshefte fur Chemie. 2026;157(7):1035-1045.
BibTex	@article{ author = {Fallah Kolamsary M and Kabirifard H and Dehpour A R and Mahdavi M and Mohammadi Khanaposhtani M}, title = {Design, Synthesis, in Vivo, and in Silico Studies of New [1,2,4] Triazolo[1,5-A]Pyrimidine-7(4H)-One Derivatives As Potent Anticonvulsant Agents}, journal = {Monatshefte fur Chemie}, volume = {157}, number = {7}, pages = {1035-1045}, year = {2026} }
RIS	TY - JOUR AU - Fallah Kolamsary M AU - Kabirifard H AU - Dehpour A R AU - Mahdavi M AU - Mohammadi Khanaposhtani M TI - Design, Synthesis, in Vivo, and in Silico Studies of New [1,2,4] Triazolo[1,5-A]Pyrimidine-7(4H)-One Derivatives As Potent Anticonvulsant Agents JO - Monatshefte fur Chemie VL - 157 IS - 7 SP - 1035 EP - 1045 PY - 2026 ER -

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