Identification of Common Key Genes and Pathways Between Type 1 Diabetes and Multiple Sclerosis Using Transcriptome and Interactome Analysis

Identification of Common Key Genes and Pathways Between Type 1 Diabetes and Multiple Sclerosis Using Transcriptome and Interactome Analysis Publisher Pubmed

Safarialighiarloo N¹ ; Taghizadeh M² ; Mohammad Tabatabaei S³ ; Namaki S⁴ ; Rezaeitavirani M⁵

Show Affiliations

1. Endocrine Research Center, Institute of Endocrinology and Metabolism, Iran University of Medical Sciences, Tehran, Iran
2. Bioinformatics Department, Institute of Biochemistry and Biophysics, Tehran University, Tehran, Iran
3. Medical Informatics Department, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
4. Immunology Department, Faculty of Medical Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran
5. Proteomics Research Center, Department of Basic Science, Faculty of Paramedical Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran

Source: Endocrine Published:2020

Abstract

Purpose: Type 1 diabetes (T1D) and multiple sclerosis (MS) are classified as T cell-mediated autoimmune diseases. Although convergent evidence proposed common genetic architecture for autoimmune diseases, it remains a challenge to identify them. This study aimed to determine common gene signature and pathways in T1D and MS via systems biology approach. Methods: Gene expression profiles of peripheral blood mononuclear cells (PBMCs) and pancreatic-β cells in T1D as well as PBMCs and cerebrospinal fluid (CSF) in MS were analyzed in our previous published data, and differential expressed genes were integrated with protein–protein interactions data to construct Query–Query PPI (QQPPI) networks. In this study, QQPPI networks were further analyzed to investigate more central genes, functional modules and complexes shared in T1D and MS progression. Lastly, the interaction of common genes with drugs was also explored. Results: Several cytokines such as IL-23A, IL-32, IL-34, and IL-37 tend to be differentially expressed in both diseases. In addition, PSMA1, MYC, SRPK1, YBX1, HNRNPM, NF-κB2, IKBKE, RAC1, FN1, ARRB2, ESR1, HSP90AB1, and PPP1CA were common high central genes in QQPPI networks corresponding to each disease. Proteasome, spliceosome, immune responses, apoptosis, cellular communication/signaling transduction mechanism, interaction with environment, and activity of intercellular mediators were shared biological processes in T1D and MS. Finally, azathioprine, melatonin, resveratrol, and geldanamycin identified as prioritized drugs for the treatment of patients with T1D and MS. Conclusions: This study represented novel key genes and pathways shared between T1D and MS, which may facilitate the identification of potential therapeutic targets in these diseases. © 2020, Springer Science+Business Media, LLC, part of Springer Nature.

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Style	Citing Format
MLA	Safarialighiarloo N, et al.. "Identification of Common Key Genes and Pathways Between Type 1 Diabetes and Multiple Sclerosis Using Transcriptome and Interactome Analysis." Endocrine, vol. 68, no. 1, 2020, pp. 81-92.
APA	Safarialighiarloo N, Taghizadeh M, Mohammad Tabatabaei S, Namaki S, Rezaeitavirani M (2020). Identification of Common Key Genes and Pathways Between Type 1 Diabetes and Multiple Sclerosis Using Transcriptome and Interactome Analysis. Endocrine, 68(1), 81-92.
Chicago	Safarialighiarloo N, Taghizadeh M, Mohammad Tabatabaei S, Namaki S, Rezaeitavirani M. "Identification of Common Key Genes and Pathways Between Type 1 Diabetes and Multiple Sclerosis Using Transcriptome and Interactome Analysis." Endocrine 68, no. 1 (2020): 81-92.
Harvard	Safarialighiarloo N et al. (2020) 'Identification of Common Key Genes and Pathways Between Type 1 Diabetes and Multiple Sclerosis Using Transcriptome and Interactome Analysis', Endocrine, 68(1), pp. 81-92.
Vancouver	Safarialighiarloo N, Taghizadeh M, Mohammad Tabatabaei S, Namaki S, Rezaeitavirani M. Identification of Common Key Genes and Pathways Between Type 1 Diabetes and Multiple Sclerosis Using Transcriptome and Interactome Analysis. Endocrine. 2020;68(1):81-92.
BibTex	@article{ author = {Safarialighiarloo N and Taghizadeh M and Mohammad Tabatabaei S and Namaki S and Rezaeitavirani M}, title = {Identification of Common Key Genes and Pathways Between Type 1 Diabetes and Multiple Sclerosis Using Transcriptome and Interactome Analysis}, journal = {Endocrine}, volume = {68}, number = {1}, pages = {81-92}, year = {2020} }
RIS	TY - JOUR AU - Safarialighiarloo N AU - Taghizadeh M AU - Mohammad Tabatabaei S AU - Namaki S AU - Rezaeitavirani M TI - Identification of Common Key Genes and Pathways Between Type 1 Diabetes and Multiple Sclerosis Using Transcriptome and Interactome Analysis JO - Endocrine VL - 68 IS - 1 SP - 81 EP - 92 PY - 2020 ER -

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