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Role of Long Non-Coding Rnas in Cholangiocarcinoma: A Systematic Review and Meta-Analysis Publisher Pubmed



Shobeiri P1, 2, 3 ; Arabzadeh Bahri R1, 4 ; Khadembashiri MM5, 6 ; Khadembashiri MA5, 6 ; Maleki S7 ; Eslami M6 ; Khalili Dehkordi M1 ; Behnoush AH1, 2 ; Rezaei N2, 3, 8
Authors
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Authors Affiliations
  1. 1. School of medicine, Tehran University of Medical Sciences, Tehran, Iran
  2. 2. Network of Immunity in Infection, Malignancy and Autoimmunity (NIIMA), Universal Scientific Education and Research Network (USERN), Tehran, Iran
  3. 3. Research Center for Immunodeficiencies, Pediatrics Center of Excellence, Children's Medical Center, Tehran University of Medical Sciences, Tehran, Iran
  4. 4. Urology Research Center, Tehran University of Medical Sciences, Tehran, Iran
  5. 5. Neuromusculoskeletal Research Center, Iran University of Medical Sciences, Tehran, Iran
  6. 6. Student Scientific Research Center (SSRC), Tehran University of Medical Sciences, Tehran, Iran
  7. 7. School of Medicine, Guilan University of Medical Sciences, Rasht, Iran
  8. 8. Department of Immunology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran

Source: Cancer Reports Published:2024


Abstract

Background: Cholangiocarcinoma (CCA), as a rare malignancy of the biliary tree, has a poor prognosis most of the time. CCA is highly epigenetically regulated and several long non-coding RNAs (lncRNA) have been investigated to have a diagnostic and prognostic role in CCA. The current study aimed to assess the studies finding relevant lncRNAs in CCA systematically. Methods: International databases, including PubMed, Cochrane Library, and Embase, were comprehensively searched in order to identify studies investigating any lncRNA in CCA. After screening by title/abstract and full-text, necessary data were extracted. Random-effect meta-analysis was performed for pooling the areas under the curve (AUCs), specificity, and sensitivity of lncRNAs for the diagnosis of CCA. Results: A total of 33 studies were chosen to be included in the final analysis, comprised of 2677 patients. Meta-analysis of AUCs for evaluation of CCA resulted in pooled AUC of 0.79 (95% CI: 0.75–0.82; I2 = 69.11, p <.01). Additionally, overall sensitivity of 0.80 (95% CI 0.75–0.84) and specificity of 0.77 (95% CI: 0.68–0.84) were observed. Measurement of lncRANs in the assessment of CCA also improved overall survival significantly (effect size 1.61, 95% CI: 1.39–1.82). A similar result was found for progression-free survival (effect size 1.57, 95% CI: 1.20–1.93). Conclusion: Based on our findings, lncRNAs showed promising results as biomarkers in the diagnosis of CCA since they had acceptable sensitivity and specificity, in addition to the fact that improved survival in this poor prognosis cancer. Further studies might be needed to address this issue and find the best clinically useful lncRNA. © 2024 The Authors. Cancer Reports published by Wiley Periodicals LLC.
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