Diagnostic Accuracy of Serum and Urine S100a8/A9 and Serum Amyloid a in Probable Acute Abdominal Pain at Emergency Department Publisher Pubmed



Forouzan A¹ ; Masoumi K¹ ; Rahim F^{2, 3} ; Moezzi M¹ ; Khavanin A¹ ; Ranjbari N⁴ ; Saki MA⁵ ; Amoli AF¹ ; Akhiani N¹ ; Ghourchian F¹
Source: Disease Markers Published:2018

Abstract

Study Design. This study was performed to investigate the diagnostic values of some inflammatory biomarkers in abdominal pain. Methods. Patients over 18 years of age with acute recent abdominal pain who presented to the Emergency Department were evaluated. Serum and urinary samples were taken and evaluated for serum and urine S100A8/A9 and serum amyloid A. All patients were referred to a surgeon and were followed up until the final diagnosis. In the end, the final diagnosis was compared with the levels of biomarkers. Results. Of a total of 181 patients, 71 underwent surgery and 110 patients did not need surgery after they were clinically diagnosed. Mean levels of serum and urine S100A8/A9 had a significant difference between two groups, but serum amyloid A did not show. The diagnostic accuracy of serum S100A8/A9, urine S100A8/A9, and serum amyloid A was 86%, 79%, and 50%, respectively, in anticipation of the need or no need for surgery in acute abdominal pain. Conclusions. Our study showed that in acute abdominal pain, serum and urine S100A8/A9 can be useful indicators of the need for surgery, but serum amyloid A had a low and nonsignificant diagnostic accuracy. Copyright © 2018 Arash Forouzan et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.