Comparison of Proposed Modified and Original Sequential Organ Failure Assessment Scores in Predicting Icu Mortality: A Prospective, Observational, Follow-Up Study Publisher



Baradari AG¹ ; Sharifi H² ; Firouzian A¹ ; Daneshiyan M¹ ; Aarabi M³ ; Talebiyan Kiakolaye Y⁴ ; Nouraei SM⁵ ; Kiasari AZ¹ ; Habibi MR¹ ; Zeydi AE⁶ ; Sadeghi F⁷ Show Affiliations
Source: Scientifica Published:2016

Abstract

Background. The sequential organ failure assessment (SOFA) score has been recommended to triage critically ill patients in the intensive care unit (ICU). This study aimed to compare the performance of our proposed MSOFA and original SOFA scores in predicting ICU mortality. Methods. This prospective observational study was conducted on 250 patients admitted to the ICU. Both tools scores were calculated at the beginning, 24 hours of ICU admission, and 48 hours of ICU admission. Diagnostic odds ratio and receiver operating characteristic (ROC) curve were used to compare the two scores. Results. MSOFA and SOFA predicted mortality similarly with an area under the ROC curve of 0.837, 0.992, and 0.977 for MSOFA 1, MSOFA 2, and MSOFA 3, respectively, and 0.857, 0.988, and 0.988 for SOFA 1, SOFA 2, and SOFA 3, respectively. The sensitivity and specificity of MSOFA 1 in cut-off point 8 were 82.9% and 68.4%, respectively, MSOFA 2 in cut-off point 9.5 were 94.7% and 97.1%, respectively, and MSOFA 3 in cut-off point of 9.3 were 97.4% and 93.1%, respectively. There was a significant positive correlation between the MSOFA 1 and the SOFA 1 (r: 0.942), 24 hours (r: 0.972), and 48 hours (r: 0.960). Conclusion. The proposed MSOFA and the SOFA scores had high diagnostic accuracy, sensitivity, and specificity for predicting mortality. Copyright © 2016 Afshin Gholipour Baradari et al.